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CAS 104142-93-0

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Norfloxacin hydrochloride

Description:
Norfloxacin hydrochloride is a synthetic fluoroquinolone antibiotic primarily used to treat bacterial infections, particularly those affecting the urinary tract and gastrointestinal system. It is characterized by its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, functioning by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for DNA replication and transcription. The compound is typically presented as a white to off-white crystalline powder, soluble in water and methanol, and has a relatively low melting point. Norfloxacin hydrochloride is often administered orally and is known for its favorable pharmacokinetic properties, including good bioavailability. However, like other fluoroquinolones, it may be associated with side effects such as gastrointestinal disturbances, central nervous system effects, and potential tendon damage. It is important to use this antibiotic judiciously to minimize the risk of developing antibiotic resistance. As with all medications, it should be prescribed based on a thorough assessment of the patient's condition and susceptibility of the infecting organism.
Formula:C16H18FN3O3·HCl
InChI:InChI=1/C16H18FN3O3.ClH/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;/h7-9,18H,2-6H2,1H3,(H,22,23);1H
InChI key:InChIKey=JJWDELPVPRCLQN-UHFFFAOYSA-N
SMILES:C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC(F)=C(C2)N3CCNCC3.Cl
Synonyms:
  • 1-Ethyl-6-Fluoro-4-Oxo-7-Piperazin-1-Yl-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride
  • 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride (1:?)
  • Norfloxacin HCL
  • Norfloxacin hydrochloride
  • 3-Quinolinecarboxylicacid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, hydrochloride(1:)
  • 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,hydrochloride
  • Norfloxacin hydrochloride USP/EP/BP
  • Hydrochloric acid norfloxacin
  • See more synonyms
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