CAS 104186-68-7

METHOXYCARBONYL-D-NLE-GLY-ARG-PNA

Description:

Methoxycarbonyl-D-Nle-Gly-Arg-PNA, with the CAS number 104186-68-7, is a peptide nucleic acid (PNA) derivative that incorporates a methoxycarbonyl group and specific amino acid residues, including D-Nle (D-norleucine), Gly (glycine), and Arg (arginine). PNAs are synthetic polymers that mimic DNA or RNA, characterized by their ability to bind to complementary nucleic acid sequences with high specificity and affinity. This compound is notable for its potential applications in molecular biology, particularly in gene regulation and antisense therapy, due to its stability against enzymatic degradation and its ability to form stable duplexes with nucleic acids. The presence of the methoxycarbonyl group may enhance solubility and facilitate cellular uptake. Additionally, the incorporation of D-amino acids, such as D-Nle, can confer resistance to proteolytic degradation, making it a valuable tool in therapeutic and diagnostic applications. Overall, Methoxycarbonyl-D-Nle-Gly-Arg-PNA represents a significant advancement in the design of nucleic acid analogs for biotechnological and pharmaceutical purposes.

Synonyms:

• Moc-D-Nle-Gly-Arg-Pna

Methoxycarbonyl-D-Nle-Gly-Arg-pNA

CAS: 104186-68-7

Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin substrate utilized for coagulation factors IXa (FIXa) and Xa (FXa), as evidenced by studies [1] [2] [3

Formula: C₂₂H₃₄N₈O₇

Color and Shape: Solid

Molecular weight: 522.55

Ref: TM-T76619

Methoxycarbonyl-D-Nle-Gly-Arg-pNA acetate salt

CAS: 104186-68-7

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Formula: C₂₂H₃₄N₈O₇

Purity: Min. 95%

Molecular weight: 522.56 g/mol

Ref: 3D-FM110758

Methoxycarbonyl-D-Nle-Gly-Arg-pNA

CAS: 104186-68-7

Substrate for coagulation factor Xa and, in the presence of 33% ethylenene glycol, IXa (Km = 3.62 mM, pH 7.4).

Formula: C₂₂H₃₄N₈O₇

Purity: > 98%

Color and Shape: Beige Powder

Molecular weight: 522.56

Ref: 01-4012563