CAS 104206-65-7

Nitisinone

Description:

Nitisinone, with the CAS number 104206-65-7, is a synthetic organic compound primarily used in the treatment of hereditary tyrosinemia type 1, a rare genetic disorder affecting the metabolism of the amino acid tyrosine. It functions as a potent inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase, which is crucial in the catabolic pathway of tyrosine. By inhibiting this enzyme, nitisinone effectively reduces the accumulation of toxic metabolites associated with the disorder. The compound is typically administered orally and is characterized by its relatively low solubility in water, which influences its formulation and delivery. Nitisinone is generally well-tolerated, although it may have side effects, including potential liver toxicity and changes in the levels of certain metabolites. Its development has significantly improved the management of tyrosinemia, allowing patients to maintain a better quality of life. As with any medication, monitoring and dosage adjustments are essential to optimize therapeutic outcomes while minimizing adverse effects.

Formula: C₁₄H₁₀F₃NO₅

InChI: InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2

InChI key: InChIKey=OUBCNLGXQFSTLU-UHFFFAOYSA-N

SMILES: C(=O)(C1=C(N(=O)=O)C=C(C(F)(F)F)C=C1)C2C(=O)CCCC2=O

Synonyms:

• 1,3-Cyclohexanedione, 2-[2-nitro-4-(trifluoromethyl)benzoyl]-
• 2-[2-Nitro-4-(Trifluoromethyl)Benzoyl]Cyclohexane-1,3-Dione
• 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione
• Nitisinone
• Nitisone
• Nityr
• Orfadin
• Sc 0735

Nitisinone

CAS: 104206-65-7

Formula: C₁₄H₁₀F₃NO₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 329.23

Ref: 3B-N1054

2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, 95%

CAS: 104206-65-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₄H₁₀F₃NO₅

Purity: 95%

Molecular weight: 329.23

Ref: 02-H66633

Nitisinone

CAS: 104206-65-7

Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.

Formula: C₁₄H₁₀F₃NO₅

Purity: 99.63%

Color and Shape: Solid

Molecular weight: 329.23

Ref: TM-T1684

Nitisinone

CAS: 104206-65-7

Formula: C₁₄H₁₀F₃NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 329.2281

Ref: IN-DA003ESK

Nitisinone

CAS: 104206-65-7

Nitisinone

Purity: 99%

Molecular weight: 329.23g/mol

Ref: 54-PC109033

Nitisinone

CAS: 104206-65-7

Nitisinone

Purity: ≥98%

Molecular weight: 329.23g/mol

Ref: 54-BUP13792

Nitisinone

CAS: 104206-65-7

Applications Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),

Formula: C₁₄H₁₀F₃NO₅

Color and Shape: Neat

Molecular weight: 329.23

Ref: TR-N490135

2-(2-Nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione

CAS: 104206-65-7

Formula: C₁₄H₁₀F₃NO₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 329.231

Ref: 10-F213437