CAS 104344-23-2

Bisoprolol fumarate

Description:

Bisoprolol fumarate is a selective beta-1 adrenergic receptor blocker primarily used in the management of hypertension and heart failure. It is a white to off-white crystalline powder that is soluble in water and methanol, but less soluble in organic solvents like chloroform and ether. The substance is characterized by its ability to reduce heart rate and myocardial contractility, making it effective in lowering blood pressure and improving cardiac function. Bisoprolol fumarate is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. The fumarate salt form enhances its stability and solubility, facilitating better absorption in the gastrointestinal tract. As with other beta-blockers, it may have side effects such as fatigue, dizziness, and bradycardia, and it should be used with caution in patients with asthma or certain cardiovascular conditions. Overall, Bisoprolol fumarate is an important therapeutic agent in cardiovascular medicine, contributing to improved patient outcomes in various heart-related conditions.

Formula: C₁₈H₃₁NO₄C₄H₄O₄

InChI: InChI=1S/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI key: InChIKey=RZPZLFIUFMNCLY-WLHGVMLRSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(COCCOC(C)C)C=C1.C(=C/C(O)=O)\C(O)=O

Synonyms:

• (2R)-1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol
• 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (salt)
• 1-(Propan-2-Ylamino)-3-(4-{[2-(Propan-2-Yloxy)Ethoxy]Methyl}Phenoxy)Propan-2-Ol
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1) (salt)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt)
• Bisoprolol Fumarate
• Bisoprolol fumerate
• Concor
• Detensiel
• Emcor
• Emd 33512
• Emvoncor
• Eurtadal
• Isoten
• Maintate
• Monocor
• Soprol

Bisoprolol Hemifumarate

CAS: 104344-23-2, 66722-44-9

Formula: C₁₈H₃₁NO₄C₄H₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 383.49

Ref: 3B-B3994

Bisoprolol Fumarate 1.0 mg/ml in Methanol (as free base)

CAS: 104344-23-2

Color and Shape: Single Solution

Ref: 61-AMP0460.08-01

Bisoprolol Fumarate

CAS: 104344-23-2

Color and Shape: Neat

Ref: 61-FOR0460.08

BISOPROLOL FOR SYSTEM SUITABILITY CRS

CAS: 104344-23-2

BISOPROLOL FOR SYSTEM SUITABILITY CRS

Formula: C₄₀H₆₆N₂O₁₂

Color and Shape: Added Added

Molecular weight: 766.9582

Ref: 41-Y0000813

Bisoprolol fumarate

CAS: 104344-23-2

Bisoprolol fumarate

Formula: (C₁₈H₃₁NO₄)₂C₄H₄O₄

Purity: 99.7%

Color and Shape: White

Molecular weight: 766.46158

Ref: 47-1058

BISOPROLOL FUMARATE CRS

CAS: 104344-23-2

BISOPROLOL FUMARATE CRS

Formula: C₄₀H₆₆N₂O₁₂

Color and Shape: Added Added

Molecular weight: 766.9582

Ref: 41-Y0000812

BISOPROLOL FOR PEAK IDENTIFICATION CRS

CAS: 104344-23-2

BISOPROLOL FOR PEAK IDENTIFICATION CRS

Color and Shape: Added Added

Ref: 41-Y0000877

Bisoprolol Fumarate

CAS: 104344-23-2

Aromatic drugs of amino-alcohols, other than those contg more than one kind of oxygen function, their ethers and esters; salts thereof, nesoi

Formula: (C₁₈H₃₁NO₄)₂·C₄H₄O₄

Color and Shape: White Powder

Molecular weight: 766.96

Ref: 45-1075757

Bisoprolol (hemifumarate)

CAS: 104344-23-2

Formula: C₄₀H₆₆N₂O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 766.9582

Ref: IN-DA003271

Bisoprolol hemifumarate

CAS: 104344-23-2

Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart,

Formula: C₂₀H₃₃NO₆

Purity: 98.69% - 99.84%

Color and Shape: White To Offf-White Powder

Molecular weight: 383.49

Ref: TM-T0143

Bisoprolol hemifumarate salt

CAS: 104344-23-2

Formula: C₁₈H₃₁NO₄₀·5C₄H₄O₄

Purity: 98.0 - 102.0 %

Color and Shape: White to almost white powder

Molecular weight: 383.49

Ref: 7W-GP0667

Bisoprolol Hemifumarate

CAS: 104344-23-2

Formula: C₁₈H₃₁NO₄·5C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 325.45 0.5*116.07

Ref: 4Z-B-092

(±)-Bisoprolol-d7 Hemifumarate(iso-propyl-d7)

CAS: 104344-23-2

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 390.5

Ref: 3U-D7507

Bisoprolol fumarate

CAS: 104344-23-2

Formula: C₁₈H₃₁NO₄·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 766.9582

Ref: 04-C10654000

Bisoprolol Fumarate

CAS: 104344-23-2

Color and Shape: Neat

Ref: 86-MM0460.08

Bisoprolol hemifumarate

Controlled Product

CAS: 104344-23-2

Bisoprolol hemifumarate is a selective beta-1 receptor blocker that has been used in the treatment of high blood pressure, heart failure, and other cardiovascular diseases. It is a prodrug that undergoes enzymatic hydrolysis to bisoprolol in the liver. Bisoprolol hemifumarate has been shown to be effective as an adjunctive therapy for patients with bowel disease and cardiac effects such as lowering blood pressure levels. This drug also has a positive effect on the heart by increasing the levels of natriuretic peptides and decreasing the level of atrial fibrillation (AF). Bisoprolol hemifumarate can be detected in human serum or plasma samples through an analytical method involving liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS), which can then be analyzed by multivariate logistic regression to control for confounding factors such as age, gender, ethnicity, alcohol intake, and smoking status.

Formula: C₁₈H₃₁NO₄•(C₄H₄O₄)₀

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 383.48 g/mol

Ref: 3D-FB18827

Bisoprolol hemifumarate - Bio-X ™

Controlled Product

CAS: 104344-23-2

Bisoprolol is a β1- adrenergic antagonist agent that is used to treat hypertension and prevent myocardial infarction. As adrenergic neurotransmitters activate β1-receptors it causes an increase in blood pressure and heart rate. By reducing contractility and the need for oxygen through competitive inhibition of β1-adrenergic receptors, bisoprolol reduces the cardiac workload.

Formula: C₁₈H₃₁NO₄C₄H₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 383.48 g/mol

Ref: 3D-BB164256

Bisoprolol Hemifumarate

CAS: 104344-23-2

Applications A selective β-adrenergic blocker. Used as an antihypertensive.
References Tattersfield, A.E., et al.: Brit. J. Clin. Pharmacol., 18, 343 (1984), Kohli, R.S., et al.: Eur. Heart J., 6, 845 (1985), Zachariah, P.K., et al.: Clin. Ther., 15, 779 (1993),

Formula: C₁₈H₃₁NO₄·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 766.9582

Ref: TR-B510500

Bisoprolol for peak identification CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000877

Bisoprolol for system suitability CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000813