CAS 104376-79-6

Ceftriaxone disodium hemiheptahydrate

Description:

Ceftriaxone disodium hemiheptahydrate is a broad-spectrum cephalosporin antibiotic used primarily for the treatment of various bacterial infections. It is characterized by its disodium salt form, which enhances its solubility in water, making it suitable for intravenous or intramuscular administration. The hemiheptahydrate form indicates that the compound contains seven water molecules per molecule of ceftriaxone disodium, contributing to its stability and solubility. Ceftriaxone is effective against a wide range of Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics. Its mechanism of action involves inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The compound is generally well-tolerated, though it may cause side effects such as allergic reactions or gastrointestinal disturbances in some patients. Additionally, it is important to monitor renal function during treatment, as ceftriaxone is primarily excreted by the kidneys. Overall, ceftriaxone disodium hemiheptahydrate is a vital therapeutic agent in modern medicine, particularly in treating severe infections.

Formula: C₁₈H₁₈N₈O₇S₃H₂O·2Na

InChI: InChI=1S/C18H18N8O7S3.2Na.3H2O/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;;;;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);;;3*1H2/b24-8-;;;;;/t9-,15-;;;;;/m1...../s1

InChI key: InChIKey=UVEYQVBFLCMIMX-PMCOHIMVSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1CSC=4N(C)NC(=O)C(=O)N4)[H].[Na].O

Synonyms:

• (6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate
• (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, disodium salt, (6R-(6alpha,7beta(Z)))-, hydrate (2:7)
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, disodium salt, hydrate (2:7), (6R-(6alpha,7beta(Z))-
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, disodium salt, hydrate (2:7), (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, hydrate (2:7), [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)-
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2E)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, monosodium salt, monohydrate
• 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-, sodium salt, (6R,7R)- (1:1)
• Ceftriaxone disodium hemiheptahydrate
• Ceftriaxone disodium salt hemiheptahydrate
• disodium (6R,7R)-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-6-oxido-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate trihydrate

Ceftriaxone Disodium Salt Hemiheptahydrate

CAS: 104376-79-6, 73384-59-5, 74578-69-1

Formula: C₁₈H₁₆N₈Na₂O₇S₃H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 661.58

Ref: 3B-C2226

Ceftriaxone disodium salt, 50 mg/ml in distilled water

CAS: 104376-79-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Ref: 02-J67171

Ceftriaxone sodium hemiheptahydrate

CAS: 104376-79-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₃₆H₄₆N₁₆Na₄O₂₁S₆

Purity: 98%

Color and Shape: White to pale cream or pale yellow, Crystals or powder or crystalline powder

Molecular weight: 1323.17

Ref: 02-J66003

Ceftriaxone Sodium Hemiheptahydrate

CAS: 104376-79-6

Color and Shape: Neat

Ref: 61-FOR0251.00

CEFTRIAXONE SODIUM CRS

CAS: 104376-79-6

CEFTRIAXONE SODIUM CRS

Formula: C₁₀H₁₆N₂O₂

Color and Shape: Added Modified

Molecular weight: 196.2462

Ref: 41-C0691000

Ceftriaxone sodium

CAS: 104376-79-6

Ceftriaxone sodium

Formula: C₁₈H₁₆N₈Na₂O₇S₃

Purity: 88.6%

Color and Shape: White To Off-White

Molecular weight: 598.00995

Ref: 47-976

Ceftriaxone Sodium

CAS: 104376-79-6

Antibiotics nesoi

Formula: C₁₈H₁₆N₈Na₂O₇S₃H₂O

Color and Shape: White Yellow Orange Powder

Molecular weight: 661.6

Ref: 45-1098184

Ceftriaxone sodium hydrate

CAS: 104376-79-6

Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Formula: C₁₈H₁₆N₈Na₂O₇S₃·5H₂O

Purity: 99.77% - 99.78%

Color and Shape: White Or Almost White Crystalline Powder Odorless

Molecular weight: 661.6

Ref: TM-T1223

Ceftriaxone disodium salt

CAS: 104376-79-6

Formula: C₃₆H₄₆N₁₆Na₄O₂₁S₆

Purity: %

Color and Shape: Solid

Molecular weight: 1323.1941

Ref: IN-DA003OQH

Ceftriaxone disodium salt hemi(heptahydrate)

CAS: 104376-79-6

Formula: C₁₈H₁₆N₈Na₂O₇S₃·5H₂O

Purity: 95.0 - 102.0 % (anhydrous basis)

Color and Shape: White or pale yellow crystalline powder

Molecular weight: 661.60

Ref: 7W-GA6812

Ceftriaxone sodium hydrate

CAS: 104376-79-6

Ceftriaxone sodium hydrate

Purity: ≥80%

Molecular weight: 661.6g/mol

Ref: 54-BUP14914

Ceftriaxone Sodium Hemiheptahydrate

Controlled Product

CAS: 104376-79-6

Formula: C₁₈H₁₆N₈O₇S₃NaH₂O

Color and Shape: Neat

Molecular weight: 1323.19

Ref: 86-MM0251.00

Ceftriaxone sodium hemiheptahydrate

Controlled Product

CAS: 104376-79-6

Formula: C₁₈H₁₆N₈O₇S₃NaH₂O

Color and Shape: Neat

Molecular weight: 1323.19

Ref: 04-C11065200

Ceftriaxone Disodium Salt

CAS: 104376-79-6, 73384-59-5

Formula: C₁₈H₁₆N₈O₇S₃·2Na

Molecular weight: 552.57 2*22.99

Ref: 4Z-C-939

Ceftriaxone Sodium RS

CAS: 104376-79-6

Color and Shape: White To Yellowish White Solid Crystalline Powder

Ref: 2K-7000590021

Ceftriaxone Disodium Hemiheptahydrate

CAS: 104376-79-6

Applications An antibacterial, a third-generation cephalosporin.
References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)

Formula: C₁₈H₁₈N₈Na₂O₇S₃H₂O

Color and Shape: Neat

Molecular weight: 1323.19

Ref: TR-C245000

Ceftriaxone sodium hydrate - Bio-X ™

CAS: 104376-79-6

Ceftriaxone is a broad-spectrum cephalosporin antibiotic that is used for the treatment of bacterial infections in different locations such as the skin, soft tissue and respiratory tract. This drug works by inhibiting mucopeptide synthesis in the bacterial cell wall. As a result, bacteria will produce defective cell walls leading to cell death.

Formula: C₁₈H₁₆N₈Na₂O₇S₃·5H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 661.6 g/mol

Ref: 3D-BC166388

Ceftriaxone disodium hemiheptahydrate

CAS: 104376-79-6

Ceftriaxone disodium hemiheptahydrate is a third-generation cephalosporin antibiotic, which is a semisynthetic derivative of cephalosporin C. This compound is sourced from the fungus Acremonium, which is known for its role in deriving crucial β-lactam antibiotics. Ceftriaxone acts by inhibiting bacterial cell wall synthesis, specifically targeting the penicillin-binding proteins (PBPs). This action disrupts peptidoglycan cross-linking, leading to bacterial cell lysis and death.

Formula: (C₁₈H₁₈N₈Na₂O₇S₃)₂•(H₂O)₇

Purity: Min. 94 Area-%

Color and Shape: White Yellow Powder

Molecular weight: 1,327.23 g/mol

Ref: 3D-AC29658

Ceftriaxone Disodium Salt Hemiheptahydrate (CFTZ)

CAS: 104376-79-6

Formula: C₁₈H₁₆N₈Na₂O₇S₃·5H₂O

Color and Shape: White to yellow, Crystalline powder

Molecular weight: 661.60

Ref: SR-79364

Ceftriaxone Disodium Salt Hemiheptahydrate (CFTZ) ExiPlus, Multi-Compendial

CAS: 104376-79-6

Formula: C₁₈H₁₆N₈Na₂O₇S₃·5H₂O

Molecular weight: 661.60

Ref: SR-13081