CAS 1044589-82-3

7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Description:

7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a chemical compound that belongs to a class of nucleoside analogs, which are often studied for their potential antiviral and anticancer properties. This compound features a pyrrolo[2,3-d]pyrimidine core, which is a bicyclic structure that contributes to its biological activity. The presence of the ethynyl group at the 2-C position of the ribofuranosyl moiety enhances its stability and may influence its interaction with biological targets, such as enzymes involved in nucleic acid synthesis. The β-D-ribofuranosyl component is indicative of its nucleoside-like characteristics, which can facilitate incorporation into nucleic acids. The compound's unique structure may allow it to mimic natural nucleosides, potentially interfering with viral replication or cancer cell proliferation. Its specific properties, such as solubility, stability, and reactivity, would depend on the surrounding conditions and the presence of other chemical entities. Further studies would be necessary to fully elucidate its pharmacological profile and therapeutic potential.

Formula: C₁₃H₁₄N₄O₄

InChI: InChI=1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1

InChI key: InChIKey=NKRAIOQPSBRMOV-NRMKKVEVSA-N

SMILES: C(#C)[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(C=C2)=C(N)N=CN3

Synonyms:

• 7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• NITD 008
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-ethynyl-β-D-ribofuranosyl)-
• 7-Deaza-2′-C-acetylene-adenosine
• (2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
• 7-Deaza-2'-C-ethynyladenosine
• NITD008

7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

CAS: 1044589-82-3

Formula: C₁₃H₁₄N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 290.2747

Ref: IN-DA00954G

(2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

CAS: 1044589-82-3

(2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Purity: 99%

Molecular weight: 290.28g/mol

Ref: 54-OR1066099

NITD008

Controlled Product

CAS: 1044589-82-3

Formula: C₁₃H₁₄N₄O₄

Color and Shape: Neat

Molecular weight: 290.275

Ref: TR-N900615

7-Deaza-2\'-C-acetylene-adenosine

CAS: 1044589-82-3

Formula: C₁₃H₁₄N₄O₄

Molecular weight: 290.28

Ref: ST-EA-CP-B132011

7-Deaza-2'-C-ethynyladenosine

CAS: 1044589-82-3

7-Deaza-2'-C-ethynyladenosine (7DAA) is a research inhibitor that is classified as a polymerase inhibitor. It binds to the active site of the viral NS5B polymerase and inhibits RNA synthesis, which leads to virus replication. 7DAA has shown activity against hepatitis B virus (HBV) and hepatitis C virus (HCV). It also shows multifunctional properties in its inhibition of HBV genotypes A1, A3, and D1. In addition, 7DAA interacts with the RNA binding site on HCV polymerase protein and prevents binding of the viral RNA genome to this site. 7DAA also inhibits HIV replication by preventing assembly of the reverse transcriptase enzyme complex at an early stage.

Formula: C₁₃H₁₄N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 290.27 g/mol

Ref: 3D-ND15347

NITD008

CAS: 1044589-82-3

NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.

Formula: C₁₃H₁₄N₄O₄

Purity: 98.04%

Color and Shape: Solid

Molecular weight: 290.27

Ref: TM-T16325