CAS 1044746-98-6

Topotecan-d6 Hydrochloride

Description:

Topotecan-d6 Hydrochloride is a deuterated form of the chemotherapeutic agent topotecan, which is primarily used in the treatment of certain cancers, including ovarian cancer and small cell lung cancer. The "d6" designation indicates that the compound contains six deuterium atoms, which are stable isotopes of hydrogen, replacing the regular hydrogen atoms in the molecule. This modification can enhance the compound's stability and facilitate pharmacokinetic studies. Topotecan functions as a topoisomerase I inhibitor, interfering with DNA replication and transcription, ultimately leading to cell death. The hydrochloride salt form enhances its solubility in aqueous solutions, making it suitable for intravenous administration. In terms of physical properties, Topotecan-d6 Hydrochloride is typically a white to off-white powder, and its stability and reactivity can be influenced by factors such as pH and temperature. As with other deuterated compounds, it is often used in research to trace metabolic pathways and study drug interactions due to its distinct isotopic signature.

Formula: C₂₃H₂₄ClN₃O₅

Synonyms:

• (4S)-10-[[Di(methyl-d
• )amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
• Topotecan-d6 Hydrochloride
• 3
• DGHHQBMTXTWTJV-ZSZCRZDTSA-N

Topotecan-d6 Hydrochloride

Controlled Product

CAS: 1044746-98-6

Applications Topotecan-d6 Hydrochloride is the labeled analogue of Topotecan Hydrochloride (T542500), a DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.
References Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990); BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1991); Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1992)

Formula: C₂₃D₆H₁₇N₃O₅·HCl

Color and Shape: Neat

Molecular weight: 463.944

Ref: TR-T542504