CAS 10448-84-7

Nitromifene

Description:

Nitromifene, with the CAS number 10448-84-7, is a synthetic organic compound primarily known for its application in medicinal chemistry, particularly in the context of hormone-related therapies. It is classified as a non-steroidal antiestrogen and is structurally related to the well-known antiestrogen drug tamoxifen. Nitromifene exhibits a nitro group, which contributes to its chemical reactivity and biological activity. The compound is typically characterized by its ability to bind to estrogen receptors, thereby inhibiting the effects of estrogen in target tissues, which can be beneficial in the treatment of hormone-dependent cancers, such as breast cancer. In terms of physical properties, nitromifene is generally a solid at room temperature, with specific melting and boiling points that are characteristic of its molecular structure. Safety and handling precautions are essential due to its potential toxicity and the need for proper storage conditions to maintain stability. Overall, nitromifene represents a significant compound in the field of pharmacology, particularly in the development of targeted cancer therapies.

Formula: C₂₇H₂₈N₂O₄

InChI: InChI=1/C27H28N2O4/c1-32-24-13-9-21(10-14-24)26(27(29(30)31)23-7-3-2-4-8-23)22-11-15-25(16-12-22)33-20-19-28-17-5-6-18-28/h2-4,7-16H,5-6,17-20H2,1H3/b27-26-

InChI key: InChIKey=MFKMXUFMHOCZHP-UHFFFAOYSA-N

SMILES: C(=C(N(=O)=O)C1=CC=CC=C1)(C2=CC=C(OCCN3CCCC3)C=C2)C4=CC=C(OC)C=C4

Synonyms:

• (Z)-1-(2-(4-(1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl)phenoxy)ethyl)pyrrolidine
• 1-(2-(p-(a-(p-Methoxyphenyl)-b-nitrostyryl)phenoxy)ethyl)pyrrolidine
• 1-(2-{4-[(Z)-1-(4-Methoxyphenyl)-2-nitro-2-phenylvinyl]phenoxy}ethyl)pyrrolidine
• 1-(2-{4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy}ethyl)pyrrolidine
• 1-[2-[4-[1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
• 10448-84-7
• Cn 55945
• Pyrrolidine, 1-(2-(4-(1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl)phenoxy)ethyl)-, (Z)-
• Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-
• Pyrrolidine, 1-[2-[p-[α-(p-methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]-
• pyrrolidine, 1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-
• Nitromifene
• CI628
• 1-[2-[4-[α-(4-Methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]pyrrolidine

Nitromifene

Controlled Product

CAS: 10448-84-7

Applications Nitromifene is a free base of Nitromifene Citrate (E/Z mixture) (N496700). Nitromifene citrate is a non-steroidal estrogen antagonist. It is structurally similar to Tamoxifen (T006000), which is a selective estrogen response modifier (SERM).
References Rudick, C., et al.: Endorcrinol., 144, 179 (2003); Sutherland, R., et al.: Nature, 267, 434 (1977)

Formula: C₂₇H₂₈N₂O₄

Color and Shape: Neat

Molecular weight: 444.522

Ref: TR-N496703

1-[2-[4-[1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine

CAS: 10448-84-7

1-[2-[4-[1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine is a new inhibitor of the enzyme tyrosine hydroxylase and has been shown to have clinical efficacy against neurokinin-1 receptor (NK1R) in vivo. The compound binds to the NK1R at the same site as yohimbine, an antagonist of the receptor. It is currently being tested for the treatment of autoimmune diseases and other conditions such as cancer and obesity.

Formula: C₂₇H₂₈N₂O₄

Purity: Min. 95%

Molecular weight: 444.5 g/mol

Ref: 3D-KAA44884

Nitromifene

CAS: 10448-84-7

Nitromifene is the estrogen receptor antagonist.

Formula: C₂₇H₂₈N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 444.52

Ref: TM-T16330