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CAS 104486-69-3

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(pro9)-substance P

Description:
Substance P, specifically the (pro9)-variant, is a neuropeptide that plays a crucial role in the transmission of pain and the regulation of various physiological functions. It is composed of a sequence of amino acids and is part of the tachykinin family of peptides. Characteristically, substance P is known for its involvement in inflammatory responses and its ability to act as a neurotransmitter in the central and peripheral nervous systems. It binds to neurokinin-1 (NK1) receptors, which are widely distributed in the brain and other tissues, influencing mood, anxiety, and stress responses. The (pro9)-substance P variant indicates a specific modification in its structure, which can affect its biological activity and receptor interactions. This peptide is also studied for its potential therapeutic applications in pain management and neurodegenerative diseases. Overall, substance P is significant in both physiological and pathological processes, making it a subject of interest in pharmacology and neuroscience research.
Formula:C66H102N18O13S
InChI:InChI=1/C66H102N18O13S/c1-39(2)36-47(58(90)75-43(55(71)87)29-35-98-3)80-62(94)52-24-15-34-84(52)65(97)49(38-41-18-8-5-9-19-41)81-59(91)48(37-40-16-6-4-7-17-40)79-57(89)44(25-27-53(69)85)76-56(88)45(26-28-54(70)86)77-60(92)51-23-14-33-83(51)64(96)46(21-10-11-30-67)78-61(93)50-22-13-32-82(50)63(95)42(68)20-12-31-74-66(72)73/h4-9,16-19,39,42-52H,10-15,20-38,67-68H2,1-3H3,(H2,69,85)(H2,70,86)(H2,71,87)(H,75,90)(H,76,88)(H,77,92)(H,78,93)(H,79,89)(H,80,94)(H,81,91)(H4,72,73,74)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1
SMILES:CC(C)C[C@@H](C(=N[C@@H](CCSC)C(=N)O)O)N=C([C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N=C([C@H](Cc1ccccc1)N=C([C@H](CCC(=N)O)N=C([C@H](CCC(=N)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)N=C([C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)O)O)O)O)O)O
Synonyms:
  • Substance P, pro(9)-
  • (Pro(9))substance P
  • Substance P, proline(9)-
  • Substance P, 9-L-proline-
  • N~5~-(diaminomethylidene)ornithylprolyllysylprolylglutaminylglutaminylphenylalanylphenylalanylprolylleucylmethioninamide
  • N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-methioninamide
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