CAS 1044870-39-4: Apabetalone

Description: Apabetalone, also known as RVX-208, is a small molecule that functions primarily as a selective modulator of the BET (bromodomain and extraterminal domain) proteins, particularly BRD4. It is designed to influence gene expression by inhibiting the interaction between BET proteins and acetylated histones, thereby affecting the transcription of genes involved in inflammation and cardiovascular disease. Apabetalone has been investigated for its potential therapeutic effects in conditions such as atherosclerosis and diabetes, as it may help to improve lipid profiles and reduce inflammation. The compound is characterized by its ability to selectively target specific pathways, which may lead to fewer side effects compared to broader-spectrum treatments. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety in clinical settings. As research continues, Apabetalone's role in modulating epigenetic mechanisms presents a promising avenue for developing novel therapies for various diseases.

Formula: C₂₀H₂₂N₂O₅

InChI: InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24)

InChI key: InChIKey=NETXMUIMUZJUTB-UHFFFAOYSA-N

SMILES: O=C1N=C(NC=2C=C(OC)C=C(OC)C12)C=3C=C(C(OCCO)=C(C3)C)C

Synonyms:

• 2-[4-(2-Hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone
• 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one
• 2-[4-(2-Hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one
• 4(3H)-Quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-
• 2-[4-(2-Hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-3H-quinazolin-4-one
• 4(3H)-Quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-
• RVX 208

RVX-208

CAS: 1044870-39-4

• Formula: C₂₀H₂₂N₂O₅
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 370.3991

Apabetalone

CAS: 1044870-39-4

Apabetalone (RVX000222) , an effective BET bromodomain inhibitor, has been investigated for the treatment of …

• Formula: C₂₀H₂₂N₂O₅
• Purity: 100% - ≥98%
• Color and Shape: Solid
• Molecular weight: 370.4

2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

CAS: 1044870-39-4

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 370.4049987792969

RVX 208

CAS: 1044870-39-4

Inhibitor of BET bromodomain

• Formula: C₂₀H₂₂N₂O₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 370.4 g/mol

RVX 208-d4

CAS: 1044870-39-4

• Formula: C₂₀H₁₈D₄N₂O₅
• Color and Shape: Neat
• Molecular weight: 374.42