CAS 104653-34-1

Difethialone

Description:

Difethialone is a potent anticoagulant rodenticide belonging to the class of compounds known as second-generation anticoagulants. It functions by inhibiting vitamin K epoxide reductase, which is essential for the synthesis of vitamin K-dependent clotting factors, ultimately leading to internal bleeding in rodents. This chemical is characterized by its high toxicity to target species, requiring only a single dose for effective control, which makes it particularly effective in pest management. Difethialone is typically formulated in bait products and is designed to be palatable to rodents. Its persistence in the environment is moderate, and it poses a risk to non-target species, including pets and wildlife, if ingested. As a result, its use is regulated in many jurisdictions, necessitating careful application and adherence to safety guidelines. The chemical structure of difethialone includes a thiazole ring and a phenyl group, contributing to its biological activity and effectiveness as a rodenticide.

Formula: C₃₁H₂₃BrO₂S

InChI: InChI=1S/C31H23BrO2S/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2

InChI key: InChIKey=JHELOZJAKXYVBE-UHFFFAOYSA-N

SMILES: OC1=C(C2C=3C(CC(C2)C4=CC=C(C=C4)C5=CC=C(Br)C=C5)=CC=CC3)C(=O)SC=6C1=CC=CC6

Synonyms:

• 2H-1-Benzothiopyran-2-One,3-(3-(4’-Bromo(1,1’-Biphenyl)-4-Yl)-1,2,3,4-Tetrahyd
• 2H-1-Benzothiopyran-2-one, 3-3-(4-bromo1,1-biphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl-4-hydroxy-
• 2H-1-Benzothiopyran-2-one, 3-[3-(4′-bromo[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-
• 3-[3-(4'-bromobiphenyl-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-2-hydroxy-4H-thiochromen-4-one
• 3-[3-(4'-bromobiphenyl-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2H-thiochromen-2-one
• 3-[3-(4′-Bromo[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzothiopyran-2-one
• Baraki
• Difethiarol
• Generation
• Lm 2219
• Lm2219
• Ro-1-Naphthalenyl)-4-Hydroxy-
• Rodilon

Difethialone-d4 (Mixture of Diastereomers)

CAS: 104653-34-1

Formula: C₃₁H₁₉D₄BrO₂S

Color and Shape: White To Off-White Solid

Molecular weight: 543.51

Ref: 4Z-D-147002

Difethialone (Mixture of Diastereomers)

CAS: 104653-34-1

Formula: C₃₁H₂₃BrO₂S

Color and Shape: Off-White Solid

Molecular weight: 539.49

Ref: 4Z-D-147001

Difethialone

Controlled Product

CAS: 104653-34-1

Formula: C₃₁H₂₃BrO₂S

Color and Shape: Neat

Molecular weight: 539.48

Ref: 04-C12625000

Difethialone 10 µg/mL in Acetonitrile

CAS: 104653-34-1

Formula: C₃₁H₂₃BrO₂S

Color and Shape: Single Solution

Molecular weight: 539.48

Ref: 04-L12625000AL

Difethialone-d4

Controlled Product

CAS: 104653-34-1

Applications Difethialone-d4 is the isotope labelled analog of Difethialone, which is an anticoagulant rodenticide widely used to control rodent infestations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Eason, C., et al.: Ecotoxicology, 11, 35 (2002), Hegdal, P., et al.: Environ. Toxicol. Chem., 7, 245 (1988), Stone, W., et al.: Environ. Contam. Tox., 70, 34 (2003),

Formula: C₃₁H₁₉D₄BrO₂S

Color and Shape: Light Yellow To Light Beige

Molecular weight: 543.51

Ref: TR-D445453

Difethialone

Controlled Product

CAS: 104653-34-1

Applications Difethialone is an anticoagulant rodenticide widely used to control rodent infestations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Eason, C., et al.: Ecotoxicology, 11, 35 (2002), Hegdal, P., et al.: Environ. Toxicol. Chem., 7, 245 (1988), Stone, W., et al.: Environ. Contam. Tox., 70, 34 (2003),

Formula: C₃₁H₂₃BrO₂S

Color and Shape: Off-White

Molecular weight: 539.48

Ref: TR-D445450

Difethialone

CAS: 104653-34-1

Difethialone is a coumarin derivative that has been used as an anticoagulant drug. It was first synthesized in 1951 and is still in use today. Difethialone inhibits the synthesis of prothrombin and other clotting factors by binding to the active site of the enzyme thrombin, which is responsible for the conversion of fibrinogen to fibrin. The long-term efficacy of difethialone has been evaluated using human serum samples with coumarin derivatives as substrates. The sample preparation, ionization techniques, and analytical methods were used to detect difethialone in human serum.

Formula: C₃₁H₂₃BrO₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 539.48 g/mol

Ref: 3D-FD21844

Difethialone

CAS: 104653-34-1

Difethialone is an anticoagulant rodenticide and a vitamin K antagonist.

Formula: C₃₁H₂₃BrO₂S

Color and Shape: Solid

Molecular weight: 539.48

Ref: TM-T71543