CAS 104746-03-4

R-10-MONOHYDROXY-DIHYDRO-CARBAMAZEPIN

Description:

R-10-Monohydroxy-Dihydro-Carbamazepin, identified by its CAS number 104746-03-4, is a chemical compound related to carbamazepine, a medication primarily used to treat epilepsy and bipolar disorder. This substance features a hydroxyl group, which contributes to its solubility and reactivity. The presence of the dihydro structure indicates that it has undergone partial hydrogenation, affecting its pharmacological properties. Typically, compounds like this may exhibit neuroprotective effects and can influence neurotransmitter activity in the central nervous system. The specific stereochemistry and functional groups present in R-10-Monohydroxy-Dihydro-Carbamazepin can significantly impact its biological activity, including its efficacy and side effect profile. As with many pharmaceutical compounds, understanding its characteristics, including solubility, stability, and interaction with biological targets, is crucial for its potential therapeutic applications. Further research is often necessary to fully elucidate its pharmacodynamics and pharmacokinetics.

Formula: C₁₅H₁₄N₂O₂

InChI: InChI=1/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m1/s1

SMILES: c1ccc2c(c1)C[C@H](c1ccccc1N2C(=N)O)O

Synonyms:

• (10R)-10,11-Dihydro-10-Hydroxy Carbamazepine
• R-(-)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide,R-MHD,CGP13698
• (10R)-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

(R)-Licarbazepine

CAS: 104746-03-4

Formula: C₁₅H₁₄N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 254.29

Ref: 4Z-C-1915

(R)-Licarbazepine-d4

CAS: 104746-03-4

Formula: C₁₅H₁₀D₄N₂O₂

Molecular weight: 258.31

Ref: 4Z-C-1913

(R)-10-Monohydroxy-10,11-dihydro Carbamazepine

Controlled Product

CAS: 104746-03-4

Applications (R)-10-Monohydroxy-10,11-dihydro Carbamazepine is the metabolite of Oxcarbazepine (OXC) and Eslicarbazepine acetate, (BIA 2-093, ESL), novel central nervous system drugs. ee=98% [α]d=-193 (C=1, pyridine)
References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),

Formula: C₁₅H₁₄N₂O₂

Color and Shape: Neat

Molecular weight: 254.28

Ref: TR-M546500

(R)-10-Monohydroxy-10,11-dihydro Carbamazepine-d3

Controlled Product

CAS: 104746-03-4

Applications (R)-10-Monohydroxy-10,11-dihydro Carbamazepine-d3 is labelled (R)-10-Monohydroxy-10,11-dihydro Carbamazepine which is the metabolite of Oxcarbazepine (OXC) and Eslicarbazepine acetate, (BIA 2-093, ESL), novel central nervous system drugs.
References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),

Formula: C₁₅H₁₁D₃N₂O₂

Color and Shape: White To Off-White

Molecular weight: 257.3

Ref: TR-M546502

(R)-10-Monohydroxy-10,11-dihydro carbamazepine

CAS: 104746-03-4

(R)-10-Monohydroxy-10,11-dihydro carbamazepine is a drug that has been shown to be active in vitro against human liver microsomes. It is a metabolite of carbamazepine, which is used for the treatment of neurologic disorders. (R)-10-Monohydroxy-10,11-dihydro carbamazepine has pharmacokinetic properties and plasma concentration–time curves similar to those of its parent compound. It also binds to hepatic CYP2C19 and CYP3A4 enzymes with high affinity, which leads to the inhibition of their activity. The drug has been shown to have a half life of 27 hours in CD1 mice, but it is not known how long it stays in humans.

Formula: C₁₅H₁₄N₂O₂

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 254.28 g/mol

Ref: 3D-FM26062

(R)-Licarbazepine

CAS: 104746-03-4

Formula: C₁₅H₁₄N₂O₂

Molecular weight: 254.29

Ref: ST-EA-CP-C8029