CAS 104746-04-5

Eslicarbazepine

Description:

Eslicarbazepine, with the CAS number 104746-04-5, is an antiepileptic drug primarily used in the treatment of partial-onset seizures. It is a derivative of carbamazepine and functions as a voltage-gated sodium channel blocker, which helps stabilize neuronal membranes and reduce excessive neuronal firing. The chemical structure of eslicarbazepine includes a carbamate moiety, contributing to its pharmacological properties. It is typically administered in its active form, which is the S-enantiomer of the racemic mixture of carbazepine. Eslicarbazepine is known for its favorable pharmacokinetic profile, including a relatively long half-life, which allows for once-daily dosing. Additionally, it has a lower potential for drug-drug interactions compared to some other antiepileptic medications. Common side effects may include dizziness, drowsiness, and nausea, but it is generally well-tolerated. Overall, eslicarbazepine represents an important therapeutic option for managing epilepsy, particularly in patients who may not respond adequately to other treatments.

Formula: C₁₅H₁₄N₂O₂

InChI: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m0/s1

InChI key: InChIKey=BMPDWHIDQYTSHX-AWEZNQCLSA-N

SMILES: C(N)(=O)N1C=2C([C@@H](O)CC=3C1=CC=CC3)=CC=CC2

Synonyms:

• (10S)-10,11-Dihydro-10-hydroxy Carbamazepine
• (10S)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
• (10S)-10-hydroxy-10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
• (S)-(+)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
• (S)-(+)-10,11-Dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide
• (S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
• (S)-Licarbazepine
• 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-, (10S)-
• 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-, (S)-
• Bia 2-194
• Cgp 13751
• Erelib
• Eslicarbazepine
• Pazzul
• S-(+)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide,S-MHD

(S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

CAS: 104746-04-5

Formula: C₁₅H₁₄N₂O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 254.2839

Ref: IN-DA00381Q

Eslicarbazepine

CAS: 104746-04-5

Eslicarbazepine

Purity: ≥98%

Molecular weight: 254.28g/mol

Ref: 54-BUP10754

(S)-Licarbazepine

CAS: 104746-04-5

Formula: C₁₅H₁₄N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 254.29

Ref: 4Z-C-1910

(S)-Licarbazepine-d4

CAS: 104746-04-5

Formula: C₁₅H₁₀D₄N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 258.31

Ref: 4Z-C-1914

(S)-10-Monohydroxy-10,11-dihydro Carbamazepine (Eslicarbazepine)

CAS: 104746-04-5

Applications (S)-10-Monohydroxy-10,11-dihydro Carbamazepine is the metabolite of Eslicarbazepine acetate, (BIA 2-093), (E659000) a novel central nervous system drug.
References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),

Formula: C₁₅H₁₄N₂O₂

Color and Shape: Off White

Molecular weight: 254.28

Ref: TR-M546510

(S)-10-Monohydroxy-10,11-dihydro carbamazepine

CAS: 104746-04-5

(S)-10-Monohydroxy-10,11-dihydro carbamazepine is a prodrug that is metabolized to carbamazepine. It has been shown to be effective in treating epilepsy in humans, with an optimum concentration of 20-30 micrograms/mL. The matrix effect of (S)-10-monohydroxy-10,11-dihydro carbamazepine can be reduced by sampling blood at different times of the day or by taking into account the levels of hepatic impairment or drug interactions. The optimal dose for human serum levels is between 8 and 25 micrograms/mL. (S)-10-Monohydroxy-10,11-dihydro carbamazepine may also be used to treat other conditions such as trigeminal neuralgia and postherpetic neuralgia.

Formula: C₁₅H₁₄N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 254.28 g/mol

Ref: 3D-FM26063

(S)-10-Monohydroxy-10,11-dihydro Carbamazepine-D3 (Eslicarbazepine-D3)

Controlled Product

CAS: 104746-04-5

Applications (S)-10-Monohydroxy-10,11-dihydro Carbamazepine-D3 is a labelled analogue of (S)-10-Monohydroxy-10,11-dihydro Carbamazepine (M546510), a metabolite of Eslicarbazepine acetate (E659000) a novel central nervous system drug.
References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),

Formula: C₁₅H₁₁D₃N₂O₂

Color and Shape: White To Off-White

Molecular weight: 257.3

Ref: TR-M546512

Carbamazepine Impurity 9

CAS: 104746-04-5

Formula: C₁₅H₁₄N₂O₂

Molecular weight: 254.29

Ref: ST-EA-CP-C8024

Eslicarbazepine

CAS: 104746-04-5

Eslicarbazepine (Stedesa) can be used for adjunctive therapy for adults with partial-onset seizures.

Formula: C₁₅H₁₄N₂O₂

Purity: 99.97%

Color and Shape: Off-White Solid

Molecular weight: 254.28

Ref: TM-T3285L