CAS 104757-53-1

Barnidipine Hydrochloride

Description:

Barnidipine Hydrochloride is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to selectively inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent decrease in blood pressure. Barnidipine is known for its long half-life, allowing for once-daily dosing, which can enhance patient compliance. The hydrochloride salt form improves its solubility and bioavailability. In terms of its chemical structure, Barnidipine features a dihydropyridine ring, which is essential for its pharmacological activity. Additionally, it exhibits a favorable side effect profile, with a lower incidence of reflex tachycardia compared to some other calcium channel blockers. As with any medication, it is important to consider potential interactions and contraindications, and it should be used under medical supervision to ensure safety and efficacy.

Formula: C₂₇H₃₀ClN₃O₆

InChI: InChI=1/C27H29N3O6.ClH/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19;/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3;1H/t22-,25-;/m0./s1

InChI key: InChIKey=XEMPUKIZUCIZEY-YSCHMLPRSA-N

SMILES: C(O[C@@H]1CN(CC2=CC=CC=C2)CC1)(=O)C=3[C@H](C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4.Cl

Synonyms:

• (+)-(3'S,4S)-1-Benzyl-3-Pyrrolidinyl Methyl 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylate
• (3S)-1-benzylpyrrolidin-3-yl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, hydrochloride (1:1), (4S)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester, monohydrochloride, (4S)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-pyrrolidinyl ester, monohydrochloride, [S-(R*,R*)]-
• Barnidipine Hcl
• Hydrochloride,(S-(R*,R*))-Hyl1-(Phenylmethyl)-3-Pyrrolidinyleste
• Ly198561
• Mepirodipinehydrochloride
• Ym 09730-5
• Ym09730-5
• Ym730
• Barnidipine hydrochloride
• Hypoca
• Mepirodipine
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester, (4S)-

Barnidipine hydrochloride

CAS: 104757-53-1

Formula: C₂₇H₃₀ClN₃O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 527.9966

Ref: IN-DA007XK5

Barnidipine hydrochloride

CAS: 104757-53-1

Barnidipine hydrochloride

Purity: ≥95%

Molecular weight: 528g/mol

Ref: 54-BUP11771

Barnidipine hydrochloride

CAS: 104757-53-1

Formula: C₂₇H₃₀ClN₃O₆

Molecular weight: 528.00

Ref: 7W-GP6852

Barnidipine-d5 HCl

CAS: 104757-53-1

Formula: C₂₇H₂₄D₅N₃O₆·HCl

Color and Shape: Pale Yellow Solid

Molecular weight: 496.57 36.46

Ref: 4Z-B-411

Barnidipine HCl

CAS: 104757-53-1

Formula: C₂₇H₂₉N₃O₆·HCl

Color and Shape: Pale Yellow Solid

Molecular weight: 491.55 36.46

Ref: 4Z-B-415

Barnidipine hydrochloride

CAS: 104757-53-1

Barnidipine HCl is a potent dihydropyridine Ca²⁺ blocker with 0.35 nM IC50 in pig coronary artery.

Formula: C₂₇H₃₀ClN₃O₆

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 528

Ref: TM-T5856

Barnidipine Hydrochloride

CAS: 104757-53-1

Applications 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. A potential candidate in the treatment of patients with renal parenchymal hypertension.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ohya, Y. et al.: Int. J. Clin. Pharmacol. Therap., 38, 304 (2000); Huh, W. S. et al.: Curr. Therap. Res., 61, 395 (2000); Katoh, M. et al.: Eur. J. Clin. Pharmacol., 55, 843 (2000);

Formula: C₂₇H₂₉N₃O₆·ClH

Color and Shape: Neat

Molecular weight: 528.00

Ref: TR-B118700

Barnidipine hydrochloride

CAS: 104757-53-1

Calcium channel blocker

Formula: C₂₇H₃₀ClN₃O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 528 g/mol

Ref: 3D-FB18144

Barnidipine-d5 Hydrochloride

Controlled Product

CAS: 104757-53-1

Formula: C₂₇H₂₄D₅N₃O₆·HCl

Color and Shape: Neat

Molecular weight: 496.57 + 36.46

Ref: TR-B118703