CAS 10478-42-9

3-(Methylnitrosoamino)propanoic acid

Description:

3-(Methylnitrosoamino)propanoic acid, with the CAS number 10478-42-9, is a chemical compound that belongs to the class of nitrosoamines, which are known for their potential carcinogenic properties. This substance features a propanoic acid backbone with a methylnitrosoamino group, which contributes to its biological activity. It is typically characterized by its molecular structure, which includes a nitroso group (-NO) attached to an amino group (-NH) and a carboxylic acid (-COOH) functional group. The presence of these functional groups suggests that the compound may participate in various chemical reactions, including nucleophilic substitutions and acid-base reactions. In biological systems, nitrosoamines are often associated with metabolic activation leading to the formation of reactive intermediates that can interact with cellular macromolecules, potentially causing DNA damage. Due to these properties, 3-(Methylnitrosoamino)propanoic acid is of interest in toxicology and cancer research, highlighting the need for careful handling and study of its effects on health and the environment.

Formula: C₄H₈N₂O₃

InChI: InChI=1S/C4H8N2O3/c1-6(5-9)3-2-4(7)8/h2-3H2,1H3,(H,7,8)

InChI key: InChIKey=JZVIGHIXBBLOEB-UHFFFAOYSA-N

SMILES: N(CCC(O)=O)(N=O)C

Synonyms:

• 3-(Methylnitrosamino)Propionicacid
• 3-(Methylnitrosoamino)Propionicacid
• 3-(Methylnitrosoamino)propanoic acid
• 3-(N-Nitroso-N-Methylamino)Propionicacid
• 3-(N-Nitroso-N-methylamino)propionic acid
• 3-(N-Nitrosomethylamino)Propionicacid
• 3-[Methyl(Nitroso)Amino]Propanoic Acid
• Methyl 4-[Methyl(Nitroso)Amino]Butanoate
• N-Methyl-N-Nitroso-Beta-Alanin
• N-Methyl-N-Nitroso-Beta-Alanine
• Nmpa
• Propanoic acid, 3-(methylnitrosoamino)-

N-Nitroso-N-methyl-3-aminopropionic Acid

Controlled Product

CAS: 10478-42-9

Stability Moisture Sensitive
Applications Tobacco products have been reported to contain various N-nitroso compounds, including several volatile N-nitrosamines. Nitrosamines are known carcinogens in a wide range of animal species. The occurence of N-nitrosamino acids such as N-nitroso-N-methylaminopropionic acid, is highly correlated with levels of tobacco-specific-nitrosamines.
References Ohshima, H., et al.: Cancer Lett., 26, 153, (1985)

Formula: C₄H₈N₂O₃

Color and Shape: Neat

Molecular weight: 132.12

Ref: TR-N529200