D-Ala-Leu-Lys 7-amido-4-methylcoumarin, often abbreviated as AMC, is a synthetic peptide substrate commonly used in biochemical assays, particularly for studying proteolytic enzymes. This compound features a coumarin moiety, which is a fluorescent marker, allowing for sensitive detection in various applications. The presence of the amino acids D-alanine, leucine, and lysine contributes to its specificity as a substrate for certain proteases, enabling researchers to monitor enzyme activity through fluorescence changes upon cleavage. The structure of AMC allows it to be soluble in aqueous solutions, making it suitable for in vitro studies. Its fluorescence properties are particularly advantageous in high-throughput screening and other analytical techniques. Additionally, the compound is stable under physiological conditions, which is essential for reliable experimental results. Overall, D-Ala-Leu-Lys 7-amido-4-methylcoumarin serves as a valuable tool in enzymology and related fields, facilitating the understanding of enzyme kinetics and mechanisms.

D-ala-leu-lys 7-amido-4-methylcoumarin

104881-72-3: D-Ala-Leu-Lys 7-amido-4-methylcoumarin, often abbreviated as AMC, is a synthetic peptide substrate commonly used in biochemical assays, particularly for studying proteolytic enzymes. This compound features a coumarin moiety, which is a fluorescent marker, allowing for sensitive detection in various applications. The presence of the amino acids D-alanine, leucine, and lysine contributes to its specificity as a substrate for certain proteases, enabling researchers to monitor enzyme activity through fluorescence changes upon cleavage. The structure of AMC allows it to be soluble in aqueous solutions, making it suitable for in vitro studies. Its fluorescence properties are particularly advantageous in high-throughput screening and other analytical techniques. Additionally, the compound is stable under physiological conditions, which is essential for reliable experimental results. Overall, D-Ala-Leu-Lys 7-amido-4-methylcoumarin serves as a valuable tool in enzymology and related fields, facilitating the understanding of enzyme kinetics and mechanisms.

D-ALK-AMC, sensitive, highly specific fluorogenic substrate for plasmin.

H-D-Ala-Leu-Lys-AMC

<p>H-D-Ala-Leu-Lys-AMC hydrochloride salt is a zymogen that is the substrate for tissue plasminogen activator (tPA). It has been shown to inhibit the activity of fibrinogen and thrombin, two proteins involved in coagulation. H-D-Ala-Leu-Lys-AMC hydrochloride salt also inhibits the hydrolysis of fibrin clots by serine proteases and prevents the formation of new clots by inhibiting the activation of annexin. This drug has been shown to be effective in animal models with established atherosclerosis.</p>

CAS 104881-72-3

D-ala-leu-lys 7-amido-4-methylcoumarin

H-D-Ala-Leu-Lys-AMC

Ref: 01-4004459

H-D-Ala-Leu-Lys-AMC hydrochloride salt

Ref: 3D-FA110474