CAS 104931-87-5

Arbekacin sulfate

Description:

Arbekacin sulfate is an aminoglycoside antibiotic primarily used in the treatment of infections caused by Gram-negative bacteria, particularly in cases where other antibiotics may be ineffective due to resistance. It is a derivative of kanamycin and exhibits a broad spectrum of antibacterial activity. The compound works by inhibiting bacterial protein synthesis, ultimately leading to cell death. Arbekacin is particularly noted for its effectiveness against certain strains of methicillin-resistant Staphylococcus aureus (MRSA). In terms of its chemical properties, Arbekacin sulfate is typically presented as a sulfate salt, which enhances its solubility in aqueous solutions, making it suitable for intravenous administration. The compound is generally well-tolerated, although it can have side effects, including nephrotoxicity and ototoxicity, which are common concerns with aminoglycosides. Its use is often reserved for serious infections, and it is important to monitor renal function during treatment. Overall, Arbekacin sulfate represents a valuable option in the antibiotic arsenal, particularly in the context of multidrug-resistant bacterial infections.

Formula: C₂₂H₄₄N₆O₁₀·xH₂O₄S

InChI: InChI=1S/C22H44N6O10.H2O4S/c23-4-3-12(30)20(34)28-11-5-10(26)18(37-21-9(25)2-1-8(6-24)35-21)17(33)19(11)38-22-16(32)14(27)15(31)13(7-29)36-22;1-5(2,3)4/h8-19,21-22,29-33H,1-7,23-27H2,(H,28,34);(H2,1,2,3,4)/t8-,9+,10-,11+,12-,13+,14-,15+,16+,17-,18+,19-,21+,22+;/m0./s1

InChI key: InChIKey=UTUVRPOLEMRKQC-XDJMXTNXSA-N

SMILES: O([C@H]1[C@H](NC([C@H](CCN)O)=O)C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H]1O)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O.S(=O)(=O)(O)O

Synonyms:

• (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (1:1)
• (S)-Oxobutyl)-2-Deoxysulfate(Salt)
• 6-Tetradeoxy-Alpha-D-Erythro-Hexopyranosyl-(1-4))-N’-(4-Amino-2-Hydroxy-1-4
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-N¹-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-N¹-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (salt)
• Arbekacin sulfate
• Arbekacinsulfate
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (salt)
• D-Streptamine,O-3-Amino-3-Deoxy-Alpha-D-Glucopyranosyl-(1-6)-O-(2,6-Diamino-2,
• HBK
• Habekacin

Arbekacin Sulfate

CAS: 104931-87-5

Formula: C₂₂H₄₄N₆O₁₀·H₂O₄S

Molecular weight: 552.63 98.08

Ref: 4Z-A-130001

Arbekacin Sulfate (Technical Grade)

Controlled Product

CAS: 104931-87-5

Formula: C₂₂H₄₄N₆O₁₀·H₂O₄S

Color and Shape: Neat

Molecular weight: 650.697

Ref: TR-A767415

Arbekacin sulfate

CAS: 104931-87-5

Inhibitor of DNA replication; aminoglycoside class

Formula: C₂₂H₄₄N₆O₁₀·xH₂SO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 650.7 g/mol

Ref: 3D-AA46072

Arbekacin Sulfate

CAS: 104931-87-5

Formula: C₂₂H₄₄N₆O₁₀H₂O₄S

Molecular weight: 552.63 : 98.08

Ref: ST-EA-CP-A274000