CAS 104987-30-6

dihydro-fk 506

Description:

Dihydro-FK 506, also known as a derivative of FK-506 (tacrolimus), is an immunosuppressive agent primarily used in organ transplantation and autoimmune diseases. It functions by inhibiting T-lymphocyte activation and proliferation, thereby reducing the immune response. The substance is characterized by its potent immunosuppressive properties, which are attributed to its ability to bind to the immunophilin FKBP-12, leading to the inhibition of calcineurin and subsequent downregulation of interleukin-2 production. Dihydro-FK 506 is typically administered in a controlled manner due to its potential side effects, which can include nephrotoxicity, neurotoxicity, and increased susceptibility to infections. Its pharmacokinetics involve extensive metabolism in the liver, and it exhibits a relatively long half-life, necessitating careful monitoring of drug levels in patients. Overall, dihydro-FK 506 represents a significant advancement in immunosuppressive therapy, offering a targeted approach to managing transplant rejection and autoimmune conditions.

Formula: C₄₄H₇₁NO₁₂

InChI: InChI=1S/C44H71NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h19,21,26,28-34,36-40,46-47,52H,10-18,20,22-24H2,1-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

Synonyms:

• Dihydro-FK506

Tacrolimus 8-propyl analog (See USP Certificate for full Chemical Name)

CAS: 104987-30-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₄₄H₇₁NO₁₂

Color and Shape: White Powder

Molecular weight: 805.49763

Ref: 45-1642835

Tsukubamycin B

CAS: 104987-30-6

Tsukubamycin B, which can be isolated from Streptomyces tsukubaensis, exhibits immunosuppressive activity by inhibiting T cell activation. It is applicable in studies related to immune rejection responses.

Formula: C₄₄H₇₁NO₁₂

Color and Shape: Solid

Molecular weight: 806.03

Ref: TM-TN8454

Tacrolimus EP Impurity E (Dihydro Tacrolimus)

CAS: 104987-30-6

Formula: C₄₄H₇₁NO₁₂

Color and Shape: White To Off-White Solid

Molecular weight: 806.05

Ref: 4Z-T-394

Dihydro FK-506

Controlled Product

CAS: 104987-30-6

Impurity Tacrolimus 8-Propyl Analog (USP)
Applications A novel analog of FK-506 (F370000) macrocycle.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kino, T., et al.: J. Antibiot., 40, 1249 (1987), Motamedi, H., et al.: J. Bacteriol., 178, 5243 (1996), Dai, Y., et al.: Drug Metab. Dispos., 34, 836 (2006),

Formula: C₄₄H₇₁NO₁₂

Color and Shape: Neat

Molecular weight: 806.03

Ref: TR-D448950

Dihydro FK-506

CAS: 104987-30-6

Dihydro FK-506 is a cytosolic protein that has immunosuppressive and anti-inflammatory properties. It is an analog of cyclosporin A, which is a powerful immunosuppressant and anti-inflammatory drug. Dihydro FK-506 binds to the cytosolic protein calcineurin in the cells, inhibiting its activity and thereby suppressing immune response. This protein also inhibits the production of proinflammatory cytokines such as TNF-α and IL-1β. Dihydro FK-506 has been shown to be effective in animal models of autoimmune diseases by suppressing immune responses and reducing inflammation.

Formula: C₄₄H₇₁NO₁₂

Purity: Min. 95%

Molecular weight: 806.03 g/mol

Ref: 3D-FD21923

Tacrolimus EP Impurity E

CAS: 104987-30-6

Formula: C₄₄H₇₁NO₁₂

Molecular weight: 806

Ref: ST-EA-CP-T39013