CAS 104987-44-2

3'-(N-methyl-1,4-nicotinoyl)-5'-pivaloyltrifluorothymidine

Description:

3'-(N-methyl-1,4-nicotinoyl)-5'-pivaloyltrifluorothymidine, with the CAS number 104987-44-2, is a synthetic nucleoside analog that exhibits unique structural features and potential biological activity. This compound is characterized by the presence of a trifluoromethyl group, which enhances its lipophilicity and may influence its interaction with biological membranes. The incorporation of a pivaloyl group at the 5' position and a nicotinoyl moiety at the 3' position contributes to its stability and potential efficacy as an antiviral or anticancer agent. The N-methyl substitution on the nicotinoyl group may also affect its pharmacokinetic properties. Overall, this compound is of interest in medicinal chemistry for its potential therapeutic applications, particularly in the development of antiviral drugs, due to its ability to mimic natural nucleosides while providing enhanced properties that could improve bioavailability and target specificity. Further studies would be necessary to fully elucidate its mechanism of action and therapeutic potential.

Formula: C₂₂H₂₆F₃N₃O₇

InChI: InChI=1/C22H26F3N3O7/c1-21(2,3)19(31)33-11-15-14(35-18(30)12-6-5-7-27(4)9-12)8-16(34-15)28-10-13(22(23,24)25)17(29)26-20(28)32/h5,7,9-10,14-16H,6,8,11H2,1-4H3,(H,26,29,32)/t14-,15+,16?/m0/s1

Synonyms:

• 3'-(N-methyl-1,4-dihydronicotinoyl)-5'-pivaloyltrifluorothymidine
• Dhtft
• Thymidine, alpha,alpha,alpha-trifluoro-, 3'-(1,4-dihydro-1-methyl-3-pyridinecarboxylate) 5'-(2,2-dimethylpropanoate)
• 2'-deoxy-5'-O-(2,2-dimethylpropanoyl)-3'-O-[(1-methyl-1,4-dihydropyridin-3-yl)carbonyl]-5-(trifluoromethyl)uridine