CAS 105017-38-7
:(R,R)-(-)-Reboxetine
Description:
(R,R)-(-)-Reboxetine is a selective norepinephrine reuptake inhibitor (NRI) primarily used in the treatment of major depressive disorder. It is characterized by its chiral nature, possessing two stereocenters, which contributes to its pharmacological activity. The compound exhibits a high affinity for the norepinephrine transporter, leading to increased levels of norepinephrine in the synaptic cleft, thereby enhancing mood and alleviating depressive symptoms. Reboxetine is typically administered orally and is known for its relatively favorable side effect profile compared to other antidepressants. Its chemical structure includes a phenoxy group, which is integral to its mechanism of action. The substance is also notable for its low potential for abuse and dependence, making it a suitable option for patients with a history of substance use disorders. As with any medication, monitoring for side effects and interactions with other drugs is essential during treatment. Overall, (R,R)-(-)-Reboxetine represents a significant advancement in the pharmacotherapy of depression, particularly for individuals who may not respond to traditional selective serotonin reuptake inhibitors (SSRIs).
Formula:C19H23NO3
InChI:InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m1/s1
InChI key:InChIKey=CBQGYUDMJHNJBX-RTBURBONSA-N
SMILES:[C@@H](OC1=C(OCC)C=CC=C1)(C2=CC=CC=C2)[C@]3(CNCCO3)[H]
Synonyms:- (R,R)-(-)-Reboxetine
- (2R)-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine
- Morpholine, 2-[(2-ethoxyphenoxy)phenylmethyl]-, [R-(R*,R*)]-
- Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-
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