CAS 105355-27-9

Pioglitazone

Description:

Pioglitazone is an antidiabetic medication primarily used to manage type 2 diabetes mellitus. It belongs to the thiazolidinedione class of drugs, which function as agonists of the peroxisome proliferator-activated receptor gamma (PPAR-γ). This mechanism enhances insulin sensitivity in muscle and adipose tissue, thereby improving glucose uptake and utilization. Pioglitazone is typically administered orally and is often prescribed in conjunction with diet and exercise to achieve better glycemic control. The substance is characterized by its chemical formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, reflecting its complex structure. It is known for its potential side effects, including weight gain, edema, and an increased risk of heart failure, necessitating careful monitoring of patients. Additionally, pioglitazone has been associated with a risk of bladder cancer, leading to specific warnings regarding its use. Overall, pioglitazone plays a significant role in diabetes management, but its use must be balanced with awareness of its potential risks.

Formula: C₁₉H₂₀N₂O₃S

InChI: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)

InChI key: InChIKey=HYAFETHFCAUJAY-UHFFFAOYSA-N

SMILES: C(C1C(=O)NC(=O)S1)C2=CC=C(OCCC3=CC=C(CC)C=N3)C=C2

Synonyms:

• 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-, (±)-
• 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
• 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-
• U 72107
• Pioglitazone