CAS 10540-29-1: Tamoxifen
Description:Tamoxifen is a synthetic non-steroidal compound primarily used in the treatment and prevention of estrogen receptor-positive breast cancer. It functions as a selective estrogen receptor modulator (SERM), exhibiting both estrogenic and anti-estrogenic properties depending on the target tissue. Chemically, Tamoxifen is characterized by its biphenyl structure, which allows it to bind to estrogen receptors, thereby inhibiting the effects of estrogen in breast tissue while potentially exerting estrogen-like effects in other tissues, such as bone and the endometrium. Its molecular formula is C26H29NO, and it has a relatively high lipophilicity, which aids in its absorption and distribution in the body. Tamoxifen is typically administered orally and is known for its side effects, which can include hot flashes, risk of thromboembolic events, and potential endometrial changes. Due to its mechanism of action, Tamoxifen has been a cornerstone in breast cancer therapy, particularly for premenopausal women, and continues to be a subject of research for its broader implications in cancer treatment and prevention.
Formula:C26H29NO
InChI:InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
InChI key:InChIKey=NKANXQFJJICGDU-QPLCGJKRSA-N
SMILES:O(C1=CC=C(C=C1)C(C=2C=CC=CC2)=C(C=3C=CC=CC3)CC)CCN(C)C
- Synonyms:
- (Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
- 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
- 2-{4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
- 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
- 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
- Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
- Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
- Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-
- Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
- Genox
- See more synonyms
- Ici 47699
- Kessar
- Mammaton
- Nolvadex
- Nolvadex-D
- Novaldex
- Tamoxen
- Tamoxifen Free Base
- Tamoxifen and its salts
- Tamoxifene
- Tamoxifeno
- Z-Tamoxifen
- trans-Tamoxifen