CAS 10540-29-1

Tamoxifen

Description:

Tamoxifen is a synthetic non-steroidal compound primarily used in the treatment and prevention of estrogen receptor-positive breast cancer. It functions as a selective estrogen receptor modulator (SERM), exhibiting both estrogenic and anti-estrogenic properties depending on the target tissue. Chemically, Tamoxifen is characterized by its biphenyl structure, which allows it to bind to estrogen receptors, thereby inhibiting the effects of estrogen in breast tissue while potentially exerting estrogen-like effects in other tissues, such as bone and the endometrium. Its molecular formula is C26H29NO, and it has a relatively high lipophilicity, which aids in its absorption and distribution in the body. Tamoxifen is typically administered orally and is known for its side effects, which can include hot flashes, risk of thromboembolic events, and potential endometrial changes. Due to its mechanism of action, Tamoxifen has been a cornerstone in breast cancer therapy, particularly for premenopausal women, and continues to be a subject of research for its broader implications in cancer treatment and prevention.

Formula: C₂₆H₂₉NO

InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-

InChI key: InChIKey=NKANXQFJJICGDU-QPLCGJKRSA-N

SMILES: C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3

Synonyms:

• (Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
• 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
• 2-{4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
• 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
• 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)
• Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-
• Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-
• Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-
• Genox
• Ici 47699
• Kessar
• Mammaton
• Nolvadex
• Nolvadex-D
• Novaldex
• Tamoxen
• Tamoxifen Free Base
• Tamoxifen and its salts
• Tamoxifene
• Tamoxifeno
• Z-Tamoxifen

Tamoxifen, 98%

CAS: 10540-29-1

Tamoxifen, 10540-29-1, is an antineoplastic agent that acts by competitively binding estrogen receptors to reduce DNA synthesis. Learn more at Thermo Fisher Scientific.

Formula: C₂₆H₂₉NO

Purity: 98%

Color and Shape: Powder, White to pale cream

Molecular weight: 371.52

Ref: 02-J63509

Tamoxifen

CAS: 10540-29-1

Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast cells and an agonist in bone, liver, and uterine cells. It can be used to induce gene knockout and liver injury models in mice, and also exhibits multiple biological activities, including activation of Hsp90, induction of autophagy and apoptosis, and inhibition of EBOV and MARV viral infections.

Formula: C₂₆H₂₉NO

Purity: 98.46% - 99.97%

Color and Shape: White Solid

Molecular weight: 371.5146

Ref: TM-T6906

Tamoxifen

CAS: 10540-29-1

Formula: C₂₆H₂₉NO

Purity: ≥ 99.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 371.52

Ref: 7W-GA9513

Tamoxifen-d5 (ethyl-d5)(

CAS: 10540-29-1, 157698-32-3

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 376.55

Ref: 3U-D6637

Tamoxifen (Standard)

CAS: 10540-29-1

Tamoxifen (Standard) is a reference standard of tamoxifen, suitable for quantitative analysis, and related research such as biochemical experiments.

Formula: C₂₆H₂₉NO

Molecular weight: 371.5146

Ref: TM-TMSM-2183

Tamoxifen

Controlled Product

CAS: 10540-29-1

Formula: C₂₆H₂₉NO

Color and Shape: Neat

Molecular weight: 371.52

Ref: TR-T006000

Tamoxifen EP Impurity F-d5 HCl (N-Desmethyl Tamoxifen-d5 HCl)

CAS: 10540-29-1

Formula: C₂₅H₂₂D₅NO·HCl

Molecular weight: 362.53 36.46

Ref: 4Z-T-012

Tamoxifen

CAS: 10540-29-1

Formula: C₂₆H₂₉NO

Molecular weight: 371.52

Ref: ST-EA-CP-T40012

Tamoxifen

Controlled Product

CAS: 10540-29-1

Estrogen receptor modulator; protein kinase C inhibitor

Formula: C₂₆H₂₉NO

Purity: Min. 90%

Color and Shape: White Powder

Molecular weight: 371.51 g/mol

Ref: 3D-FT27994

Tamoxifen - Bio-X ™

Controlled Product

CAS: 10540-29-1

Tamoxifen is used as an antineoplastic agent in the treatment of breast cancer. Tamoxifen has been shown to be a competitive antagonist at the estrogen receptor, preventing estrogen from binding and activating it.  Tamoxifen is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₆H₂₉NO

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 371.51 g/mol

Ref: 3D-BT164438

Tamoxifen (1 mg/mL in Methanol)

Controlled Product

CAS: 10540-29-1

Formula: C₂₆H₂₉NO

Color and Shape: Single Solution

Molecular weight: 371.52

Ref: TR-KIT8260