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CAS 105431-72-9

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Linopirdine

Description:
Linopirdine is a chemical compound primarily recognized for its role as a selective antagonist of the M-type potassium channels, particularly the KCNQ2/3 subtypes. It is classified as a pyridine derivative and is known for its potential neuroprotective effects, making it a subject of interest in the treatment of cognitive disorders and neurodegenerative diseases. Linopirdine exhibits a moderate lipophilicity, which facilitates its ability to cross biological membranes, potentially enhancing its efficacy in the central nervous system. The compound has been studied for its ability to enhance neurotransmitter release, particularly acetylcholine, thereby improving synaptic transmission. Its pharmacological profile suggests that it may have applications in conditions such as Alzheimer's disease and other cognitive impairments. However, like many compounds in this category, its safety and efficacy profiles are critical for therapeutic use, necessitating thorough clinical evaluation. Overall, Linopirdine represents a significant area of research within neuropharmacology, with ongoing studies aimed at elucidating its full therapeutic potential.
Formula:C26H21N3O
InChI:InChI=1/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2
InChI key:InChIKey=YEJCDKJIEMIWRQ-UHFFFAOYSA-N
SMILES:C(C1(CC=2C=CN=CC2)C=3C(N(C1=O)C4=CC=CC=C4)=CC=CC3)C=5C=CN=CC5
Synonyms:
  • 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
  • 1-Phenyl-3,3-bis(4-pyridinylmethyl)-2-indolinone
  • 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
  • 1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one
  • 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-
  • Dup 996
  • Linopirdine [USAN:INN]
  • Unii-I5Tb3Nz94T
  • Linopirdine
  • linopiridine
  • See more synonyms
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