CAS 105431-72-9: Linopirdine

Description: Linopirdine is a chemical compound primarily recognized for its role as a selective antagonist of the M-type potassium channels, particularly the KCNQ2/3 subtypes. It is classified as a pyridine derivative and is known for its potential neuroprotective effects, making it a subject of interest in the treatment of cognitive disorders and neurodegenerative diseases. Linopirdine exhibits a moderate lipophilicity, which facilitates its ability to cross biological membranes, potentially enhancing its efficacy in the central nervous system. The compound has been studied for its ability to enhance neurotransmitter release, particularly acetylcholine, thereby improving synaptic transmission. Its pharmacological profile suggests that it may have applications in conditions such as Alzheimer's disease and other cognitive impairments. However, like many compounds in this category, its safety and efficacy profiles are critical for therapeutic use, necessitating thorough clinical evaluation. Overall, Linopirdine represents a significant area of research within neuropharmacology, with ongoing studies aimed at elucidating its full therapeutic potential.

Formula: C₂₆H₂₁N₃O

InChI: InChI=1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2

InChI key: InChIKey=YEJCDKJIEMIWRQ-UHFFFAOYSA-N

SMILES: O=C1N(C=2C=CC=CC2)C=3C=CC=CC3C1(CC=4C=CN=CC4)CC=5C=CN=CC5

Synonyms:

• 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
• 1-Phenyl-3,3-bis(4-pyridinylmethyl)-2-indolinone
• 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
• 1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one
• 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-
• Dup 996
• Linopirdine [USAN:INN]
• Unii-I5Tb3Nz94T
• Linopirdine

Linopirdine

CAS: 105431-72-9

Linopirdine (DuP 996) is a TRPV1 agonist.

• Formula: C₂₆H₂₁N₃O
• Purity: 99.45% - 99.78%
• Color and Shape: Solid
• Molecular weight: 391.46

1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one

CAS: 105431-72-9

• Formula: C₂₆H₂₁N₃O
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 391.4644

Linopirdine

CAS: 105431-72-9

• Purity: 99.91%
• Molecular weight: 391.46g/mol

1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE

CAS: 105431-72-9

• Purity: 95.0%
• Molecular weight: 391.4739990234375

Linopirdine

CAS: 105431-72-9

Linopirdine is an experimental drug that inhibits the activity of voltage-gated potassium channels. It has …

• Formula: C₂₆H₂₁N₃O
• Purity: Min. 95%
• Molecular weight: 391.46 g/mol