CAS 105480-29-3

2,2,2-Trifluoro-1-(1H-imidazol-2-yl)ethanone

Description:

2,2,2-Trifluoro-1-(1H-imidazol-2-yl)ethanone, with the CAS number 105480-29-3, is a chemical compound characterized by its unique trifluoroacetyl and imidazole functionalities. This substance features a trifluoromethyl group, which imparts significant electronegativity and lipophilicity, enhancing its reactivity and potential applications in various chemical reactions. The imidazole ring contributes to its biological activity, making it of interest in medicinal chemistry, particularly for its potential as a pharmacophore in drug development. The compound is typically a colorless to pale yellow liquid or solid, depending on the temperature and purity. Its polar nature, due to the presence of both the trifluoroacetyl and imidazole groups, suggests it may exhibit solubility in polar solvents. Additionally, the presence of fluorine atoms can influence its stability and reactivity, making it a valuable intermediate in organic synthesis and a subject of study for its potential applications in agrochemicals and pharmaceuticals. Safety data should be consulted for handling and storage, as fluorinated compounds can pose specific health and environmental risks.

Formula: C₅H₃F₃N₂O

InChI: InChI=1S/C5H3F3N2O/c6-5(7,8)3(11)4-9-1-2-10-4/h1-2H,(H,9,10)

InChI key: InChIKey=WSUYAJLYJNJPES-UHFFFAOYSA-N

SMILES: C(C(F)(F)F)(=O)C=1NC=CN1

Synonyms:

• 2,2,2-Trifluoro-1-(1H-imidazol-2-yl)ethanone
• 2,2,2-Trifluoro-1-(1H-imidazol-2-yl)ethan-1-one
• Ethanone, 2,2,2-trifluoro-1-(1H-imidazol-2-yl)-

2,2,2-Trifluoro-1-(1H-imidazol-2-yl)ethanone

CAS: 105480-29-3

2,2,2-Trifluoro-1-(1H-imidazol-2-yl)ethanone is a chemical that can be used in pharmacological research. It has been shown to have acidic properties and is soluble in organic solvents. 2,2,2-Trifluoro-1-(1H-imidazol-2-yl)ethanone has also been shown to inhibit DNA synthesis by binding to the topoisomerase II enzyme. 2,2,2-Trifluoroethyl ester of adriamycin has been synthesized and found to be more potent than adriamycin. The chemical structure of 2,2,2-Trifluoroethyl ester of adriamycin consists of a hydroxyl group attached to an epirubicin molecule. Spectroscopic studies have revealed that the hydroxyl group participates in hydrogen bonding with the aliphatic chain of

Formula: C₅H₃F₃N₂O

Purity: Min. 90%

Color and Shape: Powder

Molecular weight: 164.09 g/mol

Ref: 3D-FT88449