CAS 10549-91-4

Meclorisone dibutyrate

Description:

Meclorisone dibutyrate, with the CAS number 10549-91-4, is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its ability to modulate the immune response and reduce inflammation, making it effective in treating various dermatological conditions. The compound typically exhibits low solubility in water but is more soluble in organic solvents, which influences its formulation in pharmaceutical preparations. Meclorisone dibutyrate is often utilized in topical applications, allowing for localized treatment with minimal systemic absorption. Its chemical structure includes a steroid backbone, which is common among corticosteroids, contributing to its biological activity. Safety and efficacy profiles are established through clinical studies, and like other corticosteroids, it may have side effects, particularly with prolonged use. Proper handling and storage conditions are essential to maintain its stability and effectiveness. Overall, Meclorisone dibutyrate serves as a valuable therapeutic agent in managing inflammatory skin disorders.

Formula: C₃₀H₄₀Cl₂O₆

InChI: InChI=1S/C30H40Cl2O6/c1-6-8-25(35)37-17-24(34)30(38-26(36)9-7-2)18(3)14-22-21-11-10-19-15-20(33)12-13-27(19,4)29(21,32)23(31)16-28(22,30)5/h12-13,15,18,21-23H,6-11,14,16-17H2,1-5H3/t18-,21+,22+,23+,27+,28+,29+,30+/m1/s1

InChI key: InChIKey=HUXCOHMTWUSXGY-GAPIFECDSA-N

SMILES: C(COC(CCC)=O)(=O)[C@]1(OC(CCC)=O)[C@]2(C)[C@@](C[C@H]1C)([C@]3([C@](Cl)([C@@H](Cl)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]

Synonyms:

• (11Beta,16Alpha)-9,11-Dichloro-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dibutanoate
• (11β,16α)-9,11-Dichloro-16-methyl-17,21-bis(1-oxobutoxy)pregna-1,4-diene-3,20-dione
• 9,11beta-Dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate)
• 9,11beta-Dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione dibutyrate
• Butyric acid, diester with 9,11β-dichloro-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• Meclorisone dibutyrate
• Meclorisone dibutyrate [USAN]
• Pregna-1,4-diene-3,20-dione, 9,11-dichloro-16-methyl-17,21-bis(1-oxobutoxy)-, (11beta,16alpha)-
• Pregna-1,4-diene-3,20-dione, 9,11-dichloro-16-methyl-17,21-bis(1-oxobutoxy)-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9,11β-dichloro-17,21-dihydroxy-16α-methyl-, dibutyrate
• Sch 11572
• Schering No. 11572

Meclorisone Dibutyrate

Controlled Product

CAS: 10549-91-4

Applications Meclorisone Dibutyrate is used in the optimization of the bioavailability of topical steroids in humans using the thermodynamic control.
References Woodford, R., et al.: J. Invest. Dermatol., 79, 388 (1982)

Formula: C₃₀H₄₀Cl₂O₆

Color and Shape: Neat

Molecular weight: 567.541

Ref: TR-M202810

9,11b-Dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate)

Controlled Product

CAS: 10549-91-4

9,11b-Dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(butyrate) is a diagnostic agent that can be used for the diagnosis of degenerative diseases. It is a structural analog of progesterone and exhibits similar pharmacological properties. 9,11b-Dichloro-17,21-dihydroxy-16alpha-methylpregna-1,4 diene 3,20 dione 17,21 di(butyrate) has been shown to inhibit cardiac hypertrophy in rats and to reduce the size of the heart by reducing cardiac myocyte size. This drug has also been shown to reduce cavity size in diabetic patients and to lower cholesterol levels in animals. 9,11b-Dichloro 17,21 -dihydroxy 16alpha methylpregna 1 4

Formula: C₃₀H₄₁Cl₂O₈

Purity: Min. 95%

Molecular weight: 600.55 g/mol

Ref: 3D-FD170650