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CAS 105500-09-2

:

8(R)-HETE

Description:
8(R)-HETE, or 8-hydroxyeicosatetraenoic acid, is a bioactive lipid derived from arachidonic acid, which plays a significant role in various physiological processes. It is classified as a hydroxyeicosanoid, a type of eicosanoid that is involved in inflammatory responses and cellular signaling. The "R" designation indicates the specific stereochemistry of the hydroxyl group at the eighth carbon position, which is crucial for its biological activity. 8(R)-HETE is known to interact with specific receptors and can influence processes such as cell proliferation, migration, and apoptosis. Its production is typically catalyzed by lipoxygenases, enzymes that convert polyunsaturated fatty acids into various signaling molecules. The compound has been studied for its potential implications in various diseases, including cancer and cardiovascular disorders, due to its role in modulating inflammatory pathways. Additionally, its presence in biological systems can serve as a marker for certain physiological states or conditions, making it a subject of interest in biomedical research.
Formula:C20H32O3
InChI:InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-13-16-19(21)17-14-11-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,14-11-,16-13+/t19-/m0/s1
InChI key:InChIKey=NLUNAYAEIJYXRB-GTYUHVKWSA-N
SMILES:[C@@H](C/C=C\CCCC(O)=O)(/C=C/C=C\C/C=C\CCCCC)O
Synonyms:
  • (5Z,8R,9E,11Z,14Z)-8-Hydroxy-5,9,11,14-eicosatetraenoic acid
  • (5Z,8R,9E,11Z,14Z)-8-Hydroxyeicosatetraenoic acid
  • (5Z,8R,9E,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid
  • 5,9,11,14-Eicosatetraenoic acid, 8-hydroxy-, (5Z,8R,9E,11Z,14Z)-
  • 5,9,11,14-Eicosatetraenoic acid, 8-hydroxy-, [R-(E,Z,Z,Z)]-
  • 8(R)-Hete
  • [8R-(5Z,9E,11Z,14Z)]-8-Hydroxy-5,9,11,14-eicosatetraenoic acid
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