CAS 105618-26-6

Norbinaltorphimine

Description:

Norbinaltorphimine, with the CAS number 105618-26-6, is a chemical compound that belongs to the class of morphinan derivatives, specifically functioning as an opioid receptor antagonist. It is structurally related to the well-known opioid analgesics but is characterized by its ability to block the effects of opioids rather than produce them. This compound exhibits high affinity for the kappa-opioid receptor, making it a valuable tool in pharmacological research, particularly in studies related to pain management and addiction. Norbinaltorphimine's antagonistic properties can help in understanding the mechanisms of opioid action and in developing treatments for opioid dependence. Additionally, its unique structure allows for selective interaction with specific opioid receptors, which is crucial for minimizing side effects associated with non-selective opioid antagonists. Overall, Norbinaltorphimine serves as an important compound in the exploration of opioid pharmacology and therapeutic applications.

Formula: C₄₀H₄₃N₃O₆

InChI: InChI=1S/C40H43N3O6/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t27-,28-,35+,36+,37+,38+,39-,40-/m1/s1

InChI key: InChIKey=APSUXPSYBJVPPS-YAUKWVCOSA-N

SMILES: O[C@]12[C@]34[C@](C5=C(C1)C6=C(N5)[C@]7([C@]89[C@@](O)(C6)[C@](N(CC%10CC%10)CC8)(CC%11=C9C(O7)=C(O)C=C%11)[H])[H])(OC=%12C3=C(C[C@]2(N(CC%13CC%13)CC4)[H])C=CC%12O)[H]

Synonyms:

• (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)-7,12-Bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-4,8:11,15-dimethano-20H-bisbenzofuro[2,3-a:3′,2′-i]dipyrido[4,3-b:3′,4′-h]carbazole-1,8a,10a,18-tetrol
• 4,8:11,15-Dimethano-20H-bisbenzofuro(2,3-a:3',2'-i)dipyrido(4,3-b:3',4'-h)carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)-
• 4,8:11,15-Dimethano-20H-bisbenzofuro(2,3-a:3',2'-i)dipyrido(4,3-b:3',4'-h)carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-20-methyl-, (8R-(4bR*,8alpha,8abeta,10aalpha,11beta,14aR*,19aalpha,20bbeta))-
• 4,8:11,15-Dimethano-20H-bisbenzofuro[2,3-a:3′,2′-i]dipyrido[4,3-b:3′,4′-h]carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)-
• 4,8:11,15-Dimethano-20H-bisbenzofuro[2,3-a:3′,2′-i]dipyrido[4,3-b:3′,4′-h]carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, [8R-(4bS*,8α,8aβ,10aα,11β,14aS*,19aα,20bβ)]-
• 5,16-dicyclopropyl-4,5,7,8,10,11,13,14,16,17,22,22b-dodecahydro-21aH-6,9:12,15-dimethanobisazocino[4',5',6':3,4][1]benzofuro[2,3-a:3',2'-i]carbazole-1,9,12,20-tetrol
• N-Demethylbinaltorphimine
• N-Demethylbinaltrorphimine
• Nor-binaltorphimine
• Nor-bni
• NorBNI
• Norbinaltorphimine
• Norbinaltorphine

nor-Binaltorphimine dihydrochloride

CAS: 105618-26-6

Formula: C₄₀H₄₅Cl₂N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 734.7078

Ref: IN-DA007E1D

nor-Binaltorphimine dihydrochloride

CAS: 105618-26-6

Formula: C₄₀H₄₃N₃O₆·2HCl

Molecular weight: 734.71

Ref: 7W-GP8073

nor-Binaltorphimine

Controlled Product

CAS: 105618-26-6

Stability Hygroscopic
Applications nor-Binaltorphimine dihydrochloride is a selective KOR antagonist.

Formula: C₄₀H₄₃N₃O₆

Color and Shape: Neat

Molecular weight: 661.79

Ref: TR-B387043

nor-Binaltorphimine

Controlled Product

CAS: 105618-26-6

Binaltorphimine is a drug that binds to δ opioid receptors and blocks pain signals from the brain. It has been shown to have efficacy in the treatment of bowel disease, anorexia and weight loss, and chronic pain associated with osteoarthritis. Binaltorphimine has also been shown to be effective in the treatment of patients with anterior cingulate cortex injury. There is evidence that binaltorphimine can reduce the release of inflammatory mediators by blocking their synthesis at sites of injury. This drug also inhibits the binding of nonsteroidal anti-inflammatory drugs (NSAIDs) to cyclooxygenase (COX).

Formula: C₄₀H₄₃N₃O₆

Purity: (Elemental Analysis) Min. 95%

Color and Shape: Powder

Molecular weight: 661.79 g/mol

Ref: 3D-FN159650

Norbinaltorphimine

CAS: 105618-26-6

nor-Binaltorphimine dihydrochloride is a long-acting potent and highly selective kappa opioid receptor antagonist.

Formula: C₄₀H₄₃N₃O₆

Color and Shape: Solid

Molecular weight: 661.79

Ref: TM-T71523