CAS 105628-07-7: Fasudil hydrochloride
Description:Fasudil hydrochloride is a pharmacological agent primarily recognized for its role as a selective inhibitor of Rho-kinase, which is involved in various cellular processes, including smooth muscle contraction and cell migration. This compound is often utilized in the treatment of conditions such as cerebral vasospasm following subarachnoid hemorrhage and has shown potential in other therapeutic areas, including neuroprotection and cardiovascular diseases. Chemically, Fasudil hydrochloride is characterized by its molecular formula, which reflects its structure and functional groups, contributing to its biological activity. It is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. The substance exhibits a moderate to high affinity for Rho-kinase, leading to vasodilation and improved blood flow. Additionally, Fasudil hydrochloride has been studied for its effects on various signaling pathways, making it a subject of interest in research related to cell motility and proliferation. As with any pharmacological agent, its use is accompanied by potential side effects and contraindications, necessitating careful consideration in clinical applications.
Formula:C14H17N3O2S·ClH
InChI:InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChI key:InChIKey=LFVPBERIVUNMGV-UHFFFAOYSA-N
SMILES:Cl.O=S(=O)(C1=CC=CC=2C=NC=CC21)N3CCNCCC3
- Synonyms:
- 1-(5-Isoquinolinesulfinyl)hexahydro-1H-1,4-diazepine hydrochloride
- 1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride
- 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride
- Fasudil HCL
- Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride
- Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
- Eril
- Fasudil hydrochloride