CAS 105628-07-7

Fasudil hydrochloride

Description:

Fasudil hydrochloride is a pharmacological agent primarily recognized for its role as a selective inhibitor of Rho-kinase, which is involved in various cellular processes, including smooth muscle contraction and cell migration. This compound is often utilized in the treatment of conditions such as cerebral vasospasm following subarachnoid hemorrhage and has shown potential in other therapeutic areas, including neuroprotection and cardiovascular diseases. Chemically, Fasudil hydrochloride is characterized by its molecular formula, which reflects its structure and functional groups, contributing to its biological activity. It is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. The substance exhibits a moderate to high affinity for Rho-kinase, leading to vasodilation and improved blood flow. Additionally, Fasudil hydrochloride has been studied for its effects on various signaling pathways, making it a subject of interest in research related to cell motility and proliferation. As with any pharmacological agent, its use is accompanied by potential side effects and contraindications, necessitating careful consideration in clinical applications.

Formula: C₁₄H₁₇N₃O₂S·ClH

InChI: InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

InChI key: InChIKey=LFVPBERIVUNMGV-UHFFFAOYSA-N

SMILES: S(=O)(=O)(C=1C2=C(C=CC1)C=NC=C2)N3CCCNCC3.Cl

Synonyms:

• 1-(5-Isoquinolinesulfinyl)hexahydro-1H-1,4-diazepine hydrochloride
• 1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride
• 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, monohydrochloride
• Fasudil HCL
• Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride
• Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
• Eril
• Fasudil hydrochloride

Fasudil Hydrochloride

CAS: 103745-39-7, 105628-07-7, 186694-02-0

Formula: C₁₄H₁₇N₃O₂S·HCl

Purity: >96.0%(HPLC)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 327.83

Ref: 3B-F0839

Fasudil monohydrochloride, 99+%

CAS: 105628-07-7

Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against meth

Formula: C₁₄H₁₈ClN₃O₂S

Purity: 99+%

Color and Shape: White to off-white, Powder or crystals or crystalline powder

Molecular weight: 327.83

Ref: 02-J60751

1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-,monohydrochloride

CAS: 105628-07-7

Formula: C₁₄H₁₈ClN₃O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 327.8296

Ref: IN-DA00HAO6

Fasudil hydrochloride

CAS: 105628-07-7

Fasudil hydrochloride

Purity: ≥95%

Molecular weight: 327.83g/mol

Ref: 54-BUP14957

Fasudil HCl

CAS: 105628-07-7

Formula: C₁₄H₁₇N₃O₂S·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 291.37 36.46

Ref: 4Z-F-612

Fasudil Monohydrochloride Salt

CAS: 105628-07-7

Fasudil Monohydrochloride Salt

Formula: C₁₄H₁₇N₃O₂S·ClH

Purity: By hplc: 99.00% (Typical Value in Batch COA)

Color and Shape: white to almost white powder to crystals

Molecular weight: 327.83g/mol

Ref: 54-BIF105

Fasudil hydrochloride

CAS: 105628-07-7

Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.

Formula: C₁₄H₁₈ClN₃O₂S

Purity: 99.54% - ≥95%

Color and Shape: White Solid

Molecular weight: 327.83

Ref: TM-T3060

Fasudil Monohydrochloride Salt

CAS: 105628-07-7

Stability Hygroscopic
Applications Fasudil Monohydrochloride Salt is a selective ROCK inhibitor.
References Kanazawa, I., et al.: Endocr. J., 57, 415-421 (2010); Ding, J., et al.: J. Neurochem., 114, 1619-1629 (2010); Li, Y., et al.: Med. Sci. Monit., 16, BR112-BR118 (2010); Fujimura, M., et al.: Toxicol. Appl. Pharmacol., 250, 1-9 (2011);

Formula: C₁₄H₁₇N₃O₂S·ClH

Color and Shape: White To Off-White

Molecular weight: 327.83

Ref: TR-F150018

Fasudil hydrochloride

CAS: 105628-07-7

Fasudil hydrochloride is a Rho-kinase inhibitor, which is a synthetic compound derived from natural sources, primarily used in scientific research. The mode of action of Fasudil hydrochloride involves the inhibition of Rho-associated protein kinase (ROCK), a crucial player in the regulation of the actin cytoskeleton. By inhibiting ROCK, Fasudil alters various cellular functions, including contraction, motility, proliferation, and apoptosis.

Formula: C₁₄H₁₇N₃O₂S•HCl

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 327.83 g/mol

Ref: 3D-FF31090

Fasudil, Monohydrochloride Salt

CAS: 105628-07-7

Formula: C₁₄H₁₈ClN₃O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 327.83

Ref: 10-F050724