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CAS 105628-72-6

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Hydroxyfasudil

Description:
Hydroxyfasudil is a chemical compound that belongs to the class of small-molecule inhibitors, specifically targeting the Rho-associated protein kinase (ROCK) pathway. It is recognized for its potential therapeutic applications, particularly in the treatment of various neurological disorders and conditions associated with vascular dysfunction. The compound is characterized by its ability to modulate cellular signaling pathways, promoting neuroprotection and enhancing blood flow by relaxing vascular smooth muscle. Hydroxyfasudil exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a relatively low toxicity profile in preclinical studies. Its mechanism of action involves the inhibition of ROCK, which plays a crucial role in regulating cytoskeletal dynamics and cell motility. Additionally, Hydroxyfasudil has been investigated for its potential benefits in conditions such as stroke, traumatic brain injury, and certain types of cancer. As research continues, the full therapeutic potential and safety profile of Hydroxyfasudil are being explored in various clinical settings.
Formula:C14H17N3O3S
InChI:InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
InChI key:InChIKey=ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
SMILES:S(=O)(=O)(C1=C2C(C(=O)NC=C2)=CC=C1)N3CCCNCC3
Synonyms:
  • 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
  • 1H-1,4-Diazepine, 1-[(1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-
  • 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1(2H)-one
  • 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1(2H)-one hydrochloride (1:1)
  • 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
  • Ha 1100
  • Ha 1100 Hydrochloride
  • Hydroxyfasudil
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