CAS 105628-72-6

Hydroxyfasudil

Description:

Hydroxyfasudil is a chemical compound that belongs to the class of small-molecule inhibitors, specifically targeting the Rho-associated protein kinase (ROCK) pathway. It is recognized for its potential therapeutic applications, particularly in the treatment of various neurological disorders and conditions associated with vascular dysfunction. The compound is characterized by its ability to modulate cellular signaling pathways, promoting neuroprotection and enhancing blood flow by relaxing vascular smooth muscle. Hydroxyfasudil exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a relatively low toxicity profile in preclinical studies. Its mechanism of action involves the inhibition of ROCK, which plays a crucial role in regulating cytoskeletal dynamics and cell motility. Additionally, Hydroxyfasudil has been investigated for its potential benefits in conditions such as stroke, traumatic brain injury, and certain types of cancer. As research continues, the full therapeutic potential and safety profile of Hydroxyfasudil are being explored in various clinical settings.

Formula: C₁₄H₁₇N₃O₃S

InChI: InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)

InChI key: InChIKey=ZAVGJDAFCZAWSZ-UHFFFAOYSA-N

SMILES: S(=O)(=O)(C1=C2C(C(=O)NC=C2)=CC=C1)N3CCCNCC3

Synonyms:

• 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
• 1H-1,4-Diazepine, 1-[(1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-
• 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1(2H)-one
• 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1(2H)-one hydrochloride (1:1)
• 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
• Ha 1100
• Ha 1100 Hydrochloride
• Hydroxyfasudil

5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone

CAS: 105628-72-6

Formula: C₁₄H₁₇N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 307.3681

Ref: IN-DA008RE1

Hydroxyfasudil

CAS: 105628-72-6

Hydroxyfasudil

Purity: ≥98%

Molecular weight: 307.37g/mol

Ref: 54-BUP10147

5-((1,4-Diazepan-1-Yl)Sulfonyl)Isoquinolin-1(2H)-One

CAS: 105628-72-6

5-((1,4-Diazepan-1-Yl)Sulfonyl)Isoquinolin-1(2H)-One

Purity: 98%

Molecular weight: 307.37g/mol

Ref: 54-OR1023236

Fasudil Impurity 5

CAS: 105628-72-6

Formula: C₁₄H₁₇N₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 307.37

Ref: 4Z-F-619

Hydroxyfasudil

CAS: 105628-72-6

Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).

Formula: C₁₄H₁₇N₃O₃S

Purity: 98.13%

Color and Shape: Solid

Molecular weight: 307.37

Ref: TM-T4276L

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one

CAS: 105628-72-6

Formula: C₁₄H₁₇N₃O₃S

Purity: 98%

Molecular weight: 307.37

Ref: 10-F434894

Fasudil Impurity 5

CAS: 105628-72-6

Formula: C₁₄H₁₇N₃O₃S

Molecular weight: 307.37

Ref: ST-EA-CP-F131001