CAS 105635-69-6

Desferrithiocin

Description:

Desferrithiocin is a synthetic chelating agent primarily known for its ability to bind iron and other metal ions, making it significant in biomedical applications, particularly in the treatment of iron overload conditions such as thalassemia and hemochromatosis. This compound is characterized by its structure, which includes multiple functional groups that facilitate the coordination of metal ions. Desferrithiocin exhibits high affinity for ferric ions, promoting their excretion from the body, thereby reducing oxidative stress associated with excess iron. Additionally, it has been studied for its potential neuroprotective properties, as it may help mitigate the effects of metal-induced toxicity in neurological disorders. The compound is typically administered in a clinical setting, and its efficacy and safety profile are subjects of ongoing research. Overall, desferrithiocin represents a valuable tool in chelation therapy, contributing to improved patient outcomes in conditions related to metal ion dysregulation.

Formula: C₁₀H₁₀N₂O₃S·Na

InChI: InChI=1S/C10H10N2O3S.Na/c1-10(9(14)15)5-16-8(12-10)7-6(13)3-2-4-11-7;/h2-4,13H,5H2,1H3,(H,14,15);/t10-;/m1./s1

InChI key: InChIKey=JUKQSLCLJPLCKT-HNCPQSOCSA-N

SMILES: OC1=C(C2=N[C@](C(O)=O)(C)CS2)N=CC=C1.[Na]

Synonyms:

• 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-, sodium salt (1:1), (4S)-
• Desferrithiocin
• 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-, monosodium salt, (4S)-
• 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-, monosodium salt, (S)-

Desferrithiocin

CAS: 105635-69-6

Desferrithiocin is a more active iron chelator than desferrioxamine.

Formula: C₁₀H₁₀N₂O₃S

Color and Shape: Solid

Molecular weight: 238.26

Ref: TM-T31387