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CAS 105784-61-0

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TEMAFLOXACIN HYDROCHLORIDE

Description:
Temafloxacin hydrochloride is a synthetic antibiotic belonging to the fluoroquinolone class, primarily used for its antibacterial properties. It exhibits a broad spectrum of activity against various Gram-positive and Gram-negative bacteria, making it effective in treating a range of infections. The compound is characterized by its ability to inhibit bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. Temafloxacin hydrochloride is typically administered orally and is known for its favorable pharmacokinetic profile, including good absorption and distribution in body tissues. Its chemical structure includes a bicyclic core with fluorine substituents, which enhance its potency and stability. However, like other fluoroquinolones, it may be associated with potential side effects, including gastrointestinal disturbances and, in rare cases, tendon damage. Due to safety concerns and the emergence of resistance, its clinical use has become more restricted. Overall, temafloxacin hydrochloride represents an important option in the antibiotic arsenal, particularly for specific bacterial infections.
Formula:C21H19ClF3N3O3
InChI:InChI=1/C21H18F3N3O3.ClH/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23;/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30);1H
SMILES:CC1CN(CCN1)c1cc2c(cc1F)c(=O)c(cn2c1ccc(cc1F)F)C(=O)O.Cl
Synonyms:
  • Temafloxacin hydrochloride [USAN]
  • (+-)-1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
  • Abbott 62254
  • Omniflox
  • Temafloxacin HCl
  • Unii-Oc5Igj7J6I
  • 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)-
  • 1-(2,4-Difluorophenyl)-6-Fluoro-7-(3-Methylpiperazin-1-Yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride (1:1)
  • Temafloxacin hydrochloride
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Found 5 products.