CAS 1058137-23-7

Lucitanib

Description:

Lucitanib is a small molecule inhibitor primarily known for its role in targeting specific receptor tyrosine kinases, particularly those involved in cancer signaling pathways. It is characterized by its ability to inhibit the activity of fibroblast growth factor receptors (FGFRs) and platelet-derived growth factor receptors (PDGFRs), which are implicated in tumor growth and angiogenesis. Lucitanib has been investigated for its potential therapeutic applications in various cancers, including breast and lung cancer, particularly in cases with specific genetic mutations or alterations. The compound is typically administered orally and has undergone clinical trials to evaluate its efficacy and safety profile. Its chemical structure includes multiple functional groups that contribute to its biological activity and pharmacokinetic properties. As with many targeted therapies, the effectiveness of Lucitanib may vary based on the molecular characteristics of the tumor and the presence of specific biomarkers. Overall, Lucitanib represents a promising approach in the field of targeted cancer therapy, aiming to improve treatment outcomes for patients with certain malignancies.

Formula: C₂₆H₂₅N₃O₄

InChI: InChI=1S/C26H25N3O4/c1-28-25(30)19-5-3-4-16-12-17(6-7-18(16)19)33-22-8-11-29-21-14-24(23(31-2)13-20(21)22)32-15-26(27)9-10-26/h3-8,11-14H,9-10,15,27H2,1-2H3,(H,28,30)

InChI key: InChIKey=CUDVHEFYRIWYQD-UHFFFAOYSA-N

SMILES: O(C=1C2=C(C=C(OCC3(N)CC3)C(OC)=C2)N=CC1)C4=CC5=C(C=C4)C(C(NC)=O)=CC=C5

Synonyms:

• 1-Naphthalenecarboxamide, 6-[[7-[(1-aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-
• Lucitanib
• 6-[[7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-1-naphthalenecarboxamide
• AL 3810
• E 3810

Lucitanib

CAS: 1058137-23-7

Lucitanib (E-3810) is a VEGFR/FGFR inhibitor targeting VEGFR1-3 and FGFR1-2 with IC50s 7-82.5 nM.

Formula: C₂₆H₂₅N₃O₄

Purity: 96.13%

Color and Shape: Solid

Molecular weight: 443.49

Ref: TM-T15185

E-3810

CAS: 1058137-23-7

Formula: C₂₆H₂₅N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 443.4944

Ref: IN-DA008TFO

Lucitanib

CAS: 1058137-23-7

Lucitanib

Purity: ≥95%

Molecular weight: 443.49g/mol

Ref: 54-BUP04045

Lucitanib

CAS: 1058137-23-7

Purity: 98.94%

Molecular weight: 443.503

Ref: 10-F979141