Alteplase, with the CAS number 105857-23-6, is a recombinant tissue plasminogen activator (rtPA) used primarily as a thrombolytic agent in the treatment of acute myocardial infarction, pulmonary embolism, and ischemic stroke. It functions by catalyzing the conversion of plasminogen to plasmin, which leads to the breakdown of fibrin clots. Alteplase is a glycoprotein with a molecular weight of approximately 59 kDa and is produced using recombinant DNA technology. It is administered intravenously and has a relatively short half-life, necessitating careful dosing and monitoring. The drug is characterized by its specificity for fibrin-bound plasminogen, which enhances its efficacy in dissolving clots while minimizing systemic fibrinolysis. Common side effects include bleeding complications, and its use is contraindicated in patients with certain conditions, such as active bleeding or recent surgery. Overall, alteplase is a critical therapeutic agent in emergency medicine, significantly improving outcomes in patients with acute thrombotic events.

Alteplase

105857-23-6: Alteplase, with the CAS number 105857-23-6, is a recombinant tissue plasminogen activator (rtPA) used primarily as a thrombolytic agent in the treatment of acute myocardial infarction, pulmonary embolism, and ischemic stroke. It functions by catalyzing the conversion of plasminogen to plasmin, which leads to the breakdown of fibrin clots. Alteplase is a glycoprotein with a molecular weight of approximately 59 kDa and is produced using recombinant DNA technology. It is administered intravenously and has a relatively short half-life, necessitating careful dosing and monitoring. The drug is characterized by its specificity for fibrin-bound plasminogen, which enhances its efficacy in dissolving clots while minimizing systemic fibrinolysis. Common side effects include bleeding complications, and its use is contraindicated in patients with certain conditions, such as active bleeding or recent surgery. Overall, alteplase is a critical therapeutic agent in emergency medicine, significantly improving outcomes in patients with acute thrombotic events.

<p>Alteplase is human plasminogen activator (EC 3.4.21.68, that cleaves plasminogen into enzymatically active form, plasmin), recombinantly expressed in CHO cells. Alteplase belongs to the group of thrombolytic agents, and it has shown to be effective in restoring blood flow by breaking down clots.</p>

CAS 105857-23-6

Alteplase

Alteplase

Ref: 3D-FA170898