H-Gln-AMC, also known as L-Glutamine 7-amido-4-methylcoumarin, is a synthetic compound primarily used in biochemical research, particularly in the study of proteases and enzyme activity. This compound features a glutamine residue linked to a 7-amido-4-methylcoumarin moiety, which serves as a fluorescent reporter group. The characteristics of H-Gln-AMC include its ability to emit fluorescence upon cleavage by specific enzymes, making it a valuable substrate for monitoring proteolytic activity in various biological assays. The compound is typically soluble in aqueous solutions, which facilitates its use in in vitro experiments. Its fluorescence properties allow for sensitive detection and quantification, enabling researchers to study enzyme kinetics and mechanisms. Additionally, H-Gln-AMC is often utilized in drug discovery and development, particularly in screening for inhibitors of proteolytic enzymes. As with many chemical substances, proper handling and storage conditions are essential to maintain its stability and effectiveness in experimental applications.

H-Gln-AMC

105888-45-7: H-Gln-AMC, also known as L-Glutamine 7-amido-4-methylcoumarin, is a synthetic compound primarily used in biochemical research, particularly in the study of proteases and enzyme activity. This compound features a glutamine residue linked to a 7-amido-4-methylcoumarin moiety, which serves as a fluorescent reporter group. The characteristics of H-Gln-AMC include its ability to emit fluorescence upon cleavage by specific enzymes, making it a valuable substrate for monitoring proteolytic activity in various biological assays. The compound is typically soluble in aqueous solutions, which facilitates its use in in vitro experiments. Its fluorescence properties allow for sensitive detection and quantification, enabling researchers to study enzyme kinetics and mechanisms. Additionally, H-Gln-AMC is often utilized in drug discovery and development, particularly in screening for inhibitors of proteolytic enzymes. As with many chemical substances, proper handling and storage conditions are essential to maintain its stability and effectiveness in experimental applications.

Fluorogenic substrate used in a continuous spectrometric assay for glutaminyl cyclase activity.

<p>H-Gln-AMC hydrobromide salt is a protease inhibitor that prevents the breakdown of proteins by inhibiting the activity of proteases. It has been shown to have potential as a therapeutic agent for Parkinson's disease, Alzheimer's disease, and other neurodegenerative diseases. H-Gln-AMC hydrobromide salt inhibits glutaminyl cyclase and might be used in the treatment of neurodegenerative disorders.</p>

CAS 105888-45-7

H-Gln-AMC

H-Gln-AMC

Ref: 01-4003647

H-Gln-AMC hydrobromide salt

Ref: 3D-FG110498