CAS 105956-97-6

Clinafloxacin

Description:

Clinafloxacin is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria. It is known for its mechanism of action, which involves the inhibition of bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication and transcription. Clinafloxacin exhibits good oral bioavailability and is often used in the treatment of various infections, including respiratory and urinary tract infections. The compound is typically presented as a white to off-white crystalline powder, with a relatively high solubility in water, which enhances its bioavailability. Its chemical structure includes a bicyclic core with a fluorine atom and a piperazine moiety, contributing to its potency and pharmacokinetic properties. Clinafloxacin has been studied for its potential use in treating resistant bacterial strains, making it a valuable option in the antibiotic arsenal. However, like other fluoroquinolones, it may be associated with side effects, including gastrointestinal disturbances and potential effects on tendons.

Formula: C₁₇H₁₇ClFN₃O₃

InChI: InChI=1/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25)

InChI key: InChIKey=QGPKADBNRMWEQR-UHFFFAOYSA-N

SMILES: ClC1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3CC(N)CC3)C4CC4

Synonyms:

• 3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-
• 7-(3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 7-(3-Aminopyrrolidin-1-Yl)-8-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid
• 7-(3-Aminopyrrolidin-1-Yl)-8-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride (1:1)
• Pd 127391
• Clinafloxacin
• 6-Fluoro-8-chloro-1-cyclopropyl-7-(3-aminopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• CI-960
• 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Clinafloxacin

CAS: 105956-97-6

Clinafloxacin (CI-960)(PD-127391) is a fluoroquinolone antibiotic.

Formula: C₁₇H₁₇ClFN₃O₃

Purity: 96.72% - 98.87%

Color and Shape: White To Light Yellow Crystalline Powder

Molecular weight: 365.79

Ref: TM-T1283

Clinafloxacin

CAS: 105956-97-6

Formula: C₁₇H₁₇ClFN₃O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 365.7866

Ref: IN-DA007EJW

Clinafloxacin

CAS: 105956-97-6

Clinafloxacin

Purity: ≥95%

Molecular weight: 365.79g/mol

Ref: 54-BUP09678

Clinafloxacin

CAS: 105956-97-6

Formula: C₁₇H₁₇ClFN₃O₃

Molecular weight: 365.79

Ref: 7W-GA6414

Clinafloxacin

Controlled Product

CAS: 105956-97-6

Applications Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV.
References Tang G. et al.: Biochem. Pharm., 95, 227 (2015); Balwan, A. et al: Antimicrob. Agents. Chemother., 60, 1 (2016);

Formula: C₁₇H₁₇ClFN₃O₃

Color and Shape: Neat

Molecular weight: 365.79

Ref: TR-C579003

CLINAFLOXACIN

CAS: 105956-97-6

Purity: 95%

Molecular weight: 365.7900085

Ref: 10-F858786