CAS 10596-23-3

Clodronate

Description:

Clodronate is a bisphosphonate compound primarily used in the treatment of bone disorders, particularly in conditions such as osteoporosis and metastatic bone disease. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. Clodronate is characterized by its ability to bind to hydroxyapatite in bone tissue, which enhances its therapeutic effects. The chemical structure of clodronate includes two phosphonate groups, contributing to its high affinity for bone mineral. It is typically administered orally or intravenously, depending on the clinical context. Clodronate is known for its relatively low toxicity profile compared to other bisphosphonates, although it can still cause side effects such as gastrointestinal disturbances and, in rare cases, osteonecrosis of the jaw. Its pharmacokinetics involve rapid absorption and distribution, with a significant portion being retained in the bone. Overall, clodronate plays a crucial role in managing bone-related diseases, offering a therapeutic option for patients at risk of skeletal complications.

Formula: CH₄Cl₂O₆P₂

InChI: InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)

InChI key: InChIKey=ACSIXWWBWUQEHA-UHFFFAOYSA-N

SMILES: C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl

Synonyms:

• (Dichloromethanediyl)Bis(Phosphonic Acid)
• (Dichloromethylene)bis(phosphonic acid)
• 10596-23-3
• Acide Clodronique
• Acido Clodronico
• Cl 2MDP
• Clastoban
• Clodrolip
• Clodronate
• Clodroninsaure
• Clodrosome
• DMDP derivative
• Dichloromethylenebisphosphonic Acid
• Dichloromethylenediphosphonic acid
• Dmdp
• Lodronate
• Methanedichlorodiphosphonic acid
• P,P′-(Dichloromethylene)bis[phosphonic acid]
• Phosphonic acid, (dichloromethylene)bis-
• Phosphonic acid, (dichloromethylene)di-

(Dichloromethylene)diphosphonic acid

CAS: 10596-23-3

Formula: CH₄Cl₂O₆P₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 244.8924

Ref: IN-DA0039PT

Clodronic Acid

CAS: 10596-23-3

Formula: CH₄Cl₂O₆P₂

Molecular weight: 244.88

Ref: 4Z-C-219001

Clodronic Acid

Controlled Product

CAS: 10596-23-3

Applications Clodronic Acid is a bisphosphonate that can be used in the treatment of osteoporosis. Its ATP-analogs can inhibit cell signaling pathways.
References Malwal, Satish R., et al.: J. of the Ame. Chem. Soc., 140(24), 7568-7578 (2018);Chandluri, Praneeth, et al.: Indo Ame. J. of Pharma. Res., 6(8), 6495-6504 (2016)

Formula: CH₄Cl₂O₆P₂

Color and Shape: Off-White

Molecular weight: 244.892

Ref: TR-C583530

(dichloromethylene)bis(phosphonic acid)

CAS: 10596-23-3

Dichloromethylenebisphosphonic acid (DCP) is a drug that is used in the treatment of cancer. It is a chemoattractant protein, which binds to the toll-like receptor and inhibits the production of inflammatory cytokines. This agent has been shown to have anti-inflammatory properties and may be useful for the treatment of inflammation in diseases such as osteoarthritis, rheumatoid arthritis, or psoriasis. The mechanism of action of DCP involves inhibiting enzymes that are responsible for bone resorption, such as cathepsin K and matrix metalloproteinases. DCP also inhibits the proliferation of tumor cells.

Formula: CH₄Cl₂O₆P₂

Purity: Min. 95%

Molecular weight: 244.88 g/mol

Ref: 3D-KAA59623