CAS 10596-23-3: Clodronate
Description:Clodronate is a bisphosphonate compound primarily used in the treatment of bone disorders, particularly in conditions such as osteoporosis and metastatic bone disease. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. Clodronate is characterized by its ability to bind to hydroxyapatite in bone tissue, which enhances its therapeutic effects. The chemical structure of clodronate includes two phosphonate groups, contributing to its high affinity for bone mineral. It is typically administered orally or intravenously, depending on the clinical context. Clodronate is known for its relatively low toxicity profile compared to other bisphosphonates, although it can still cause side effects such as gastrointestinal disturbances and, in rare cases, osteonecrosis of the jaw. Its pharmacokinetics involve rapid absorption and distribution, with a significant portion being retained in the bone. Overall, clodronate plays a crucial role in managing bone-related diseases, offering a therapeutic option for patients at risk of skeletal complications.
Formula:CH4Cl2O6P2
InChI:InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
InChI key:InChIKey=ACSIXWWBWUQEHA-UHFFFAOYSA-N
SMILES:O=P(O)(O)C(Cl)(Cl)P(=O)(O)O
- Synonyms:
- (Dichloromethanediyl)Bis(Phosphonic Acid)
- (Dichloromethylene)bis(phosphonic acid)
- 10596-23-3
- Acide Clodronique
- Acido Clodronico
- Cl 2MDP
- Clastoban
- Clodrolip
- Clodronate
- Clodroninsaure
- See more synonyms
- Clodrosome
- DMDP derivative
- Dichloromethylenebisphosphonic Acid
- Dichloromethylenediphosphonic acid
- Dmdp
- Lodronate
- Methanedichlorodiphosphonic acid
- P,P′-(Dichloromethylene)bis[phosphonic acid]
- Phosphonic acid, (dichloromethylene)bis-
- Phosphonic acid, (dichloromethylene)di-
- Phosphonic acid, P,P'-(dichloromethylene)bis-
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(Dichloromethylene)diphosphonic acid
Ref: IN-DA0039PT
5mg | 114.00 € | ||
25mg | 155.00 € | ||
100mg | 219.00 € | ||
250mg | 579.00 € | ||
500mg | 613.00 € |
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Ref: 4Z-C-219001
5mg | To inquire | ||
10mg | To inquire | ||
25mg | To inquire | ||
50mg | To inquire | ||
100mg | To inquire |
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Clodronic Acid
Controlled ProductRef: TR-C583530
1mg | 312.00 € | ||
10mg | 2,066.00 € |
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(dichloromethylene)bis(phosphonic acid)
Ref: 3D-KAA59623
10g | 348.00 € | ||
25g | 451.00 € | ||
50g | 615.00 € | ||
100g | 905.00 € |