CAS 106128-98-7

AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH

Description:

The chemical substance with the name "AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH" and CAS number "106128-98-7" is a synthetic peptide composed of a sequence of amino acids. This peptide features a variety of functional groups characteristic of amino acids, including amine, carboxylic acid, and hydroxyl groups, which contribute to its biochemical properties. The presence of multiple polar and charged side chains suggests that this peptide may exhibit hydrophilic characteristics, potentially influencing its solubility in aqueous environments. The sequence includes essential amino acids such as lysine and arginine, which are known for their roles in protein interactions and cellular signaling. Additionally, the acetylation at the N-terminus (indicated by "AC") may enhance its stability and bioavailability. Peptides like this one are often studied for their potential applications in pharmaceuticals, biotechnology, and as research tools in understanding protein interactions and functions. Overall, the specific characteristics and behavior of this peptide would depend on its structural conformation and the context of its use.

Formula: C₅₂H₈₈N₂₂O₁₇

Synonyms:

• Myelin Basic Protein (1-11) (Guinea Pig, Horse, Porcine, Rabbit, Rat)
• Myelin Basic Protein (135-145), Human
• Ac-Mbp (Human, Porcine, Rat 1-11)
• Ac-Asqkrpsqrhg
• Acetyl-Golli-Mbp1 Hog7 (135-145) (Human)
• Acetyl-Myelin A1 Protein (135-145) (Human)
• Acetyl-Myelin Basic Protein (135-145) (Human)
• MBP (1-11), guinea pig, porcine, rabbit, rat, Myelin Basic Protein (135-145), human
• Acetyl-Golli-MBP1 HOG7 (135-145) (huMan), Acetyl-MBP (135-145) (huMan), Acetyl-Myelin A1 Protein (135-145) (huMan), Myelin Basic Protein (1-11) (guinea pig, horse, porcine, rabbit, rat)
• Glycine, N-acetyl-L-alanyl-L-seryl-L-glutaminyl-L-lysyl-L-arginyl-L-prolyl-L-seryl-L-glutaminyl-L-arginyl-L-histidyl-
• AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY
• AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH
• MBP (1-11), GUINEA PIG, PORCINE, RABBIT, RAT
• Acetyl-Myelin Basic Protein (135-145)) (hu
• 235:PN:WO2010033207 SEQID:291 claimed protein
• ACETYL-MBP (135-145) (HUMAN)
• MBP (1-11) HUMAN

Acetyl-Myelin Basic Protein (Human, Porcine, Rat, 1-11)

CAS: 106128-98-7

The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur. This can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease.
Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways.
Although more research needs to be carried out, it is thought that MBP significantly contributes to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased in and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models.

Formula: C₅₂H₈₈N₂₂O₁₇

Purity: Min. 95%

Molecular weight: 1,293.42 g/mol

Ref: 3D-PMB-3658-PI

MBP (1-11), human

CAS: 106128-98-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₅₂H₈₈N₂₂O₁₇

Molecular weight: 1,293.42 g/mol

Ref: 3D-PP50289