CAS 1061337-51-6

Lefamulin

Description:

Lefamulin is a pleuromutilin antibiotic that is primarily used for the treatment of bacterial infections, particularly those caused by Gram-positive bacteria, including strains resistant to other antibiotics. It functions by inhibiting bacterial protein synthesis through binding to the peptidyl transferase center of the 50S ribosomal subunit, thereby preventing the formation of peptide bonds. This mechanism of action makes Lefamulin effective against a range of pathogens, including Streptococcus pneumoniae and Staphylococcus aureus. The substance is typically administered intravenously or orally and is notable for its stability against common resistance mechanisms, such as those involving ribosomal mutations. Lefamulin has been approved for use in treating community-acquired pneumonia and is being investigated for other potential applications. Its pharmacokinetic profile allows for once or twice daily dosing, which enhances patient compliance. As with any antibiotic, careful consideration of its use is essential to mitigate the risk of developing antibiotic resistance.

Formula: C₂₈H₄₅NO₅S

InChI: InChI=1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16-,17+,18-,20-,21-,22-,24+,25+,26-,27+,28+/m1/s1

InChI key: InChIKey=KPVIXBKIJXZQJX-FCEONZPQSA-N

SMILES: C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CS[C@H]4[C@H](O)C[C@H](N)CC4)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]

Synonyms:

• BC-3781
• Lefamulin
• BC 3781
• Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• 2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

Lefamulin

CAS: 1061337-51-6

Lefamulin

Purity: ≥98%

Molecular weight: 507.73g/mol

Ref: 54-BUP15136

Lefamulin

CAS: 1061337-51-6

Lefamulin (BC-3781) is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow.

Formula: C₂₈H₄₅NO₅S

Purity: 99.63%

Color and Shape: Solid

Molecular weight: 507.73

Ref: TM-T7588

Lefamulin

CAS: 1061337-51-6

Lefamulin is an antibiotic, which is derived from the fermentation product of the fungus Pleuromutilin. It functions through a unique mode of action by binding to the peptidyl transferase center of the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis. This mechanism is distinct in that it interferes with key steps in the elongation phase of translation.

Formula: C₂₈H₄₅NO₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 507.7 g/mol

Ref: 3D-LSB33751

Lefamulin

Controlled Product

CAS: 1061337-51-6

Formula: C₂₈H₄₅NO₅S

Color and Shape: Neat

Molecular weight: 507.726

Ref: TR-L322795