CAS 106308-44-5
:Rufinamide
Description:
Rufinamide is an anticonvulsant medication primarily used in the treatment of Lennox-Gastaut syndrome, a severe form of epilepsy. It is characterized by its chemical formula, which includes a unique structure that allows it to modulate sodium channels, thereby stabilizing neuronal membranes and reducing seizure frequency. Rufinamide is typically administered orally and is known for its relatively favorable side effect profile compared to other antiepileptic drugs. The substance is soluble in organic solvents but has limited solubility in water, which can influence its bioavailability. Rufinamide's mechanism of action involves prolonging the inactivation of sodium channels, which helps to prevent the rapid firing of neurons associated with seizures. Additionally, it is metabolized in the liver, primarily through hydrolysis, and has a half-life that supports twice-daily dosing. Overall, Rufinamide represents an important therapeutic option for patients with refractory epilepsy, contributing to improved seizure control and quality of life.
Formula:C10H8F2N4O
InChI:InChI=1/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
InChI key:InChIKey=POGQSBRIGCQNEG-UHFFFAOYSA-N
SMILES:C(N1C=C(C(N)=O)N=N1)C2=C(F)C=CC=C2F
Synonyms:- 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
- 1-[(2,6-Difiuorophenyl)methyl]-1H-1,2,3-triazole-4 carboxamide
- 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
- 1H-1,2,3-Triazole-4-Carboxamide, 1-[(2,6-Difluorophenyl)Methyl]-
- Banzel
- Cgp 33101
- E 2080
- Inovelon
- Ruf 331
- Rufinamide
- Rufinamide, >=99%
- Rufinamide(E 2080
- RufinaMide(Banzel)
- Rufinamide, 98%, a sodium channel blocker
- Rufinamide (200 mg)
- CGP 33101; E 2080; INOVELON; RUF 331; BANZEL;E2080
- 1-[(2,6-difluorophenyl)methyl]-4-triazolecarboxamide
- CS-1133
- Rufinamide solution
- Rufinamide USP/EP/BP
- See more synonyms
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Found 13 products.
Rufinamide
CAS:Anticonvulsants, hypnotics and sedativesFormula:C10H8F2N4OColor and Shape:White Crystalline PowderMolecular weight:238.06662Rufinamide
CAS:Formula:C10H8F2N4OPurity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:238.20Rufinamide
CAS:Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.Formula:C10H8F2N4OPurity:99.77% - >99.99%Color and Shape:White PowderMolecular weight:238.19Rufinamide-d2
CAS:Controlled Product<p>Applications Labelled Rufinamide (R701552). Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant.<br>References Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),<br></p>Formula:C10H6D2F2N4OColor and Shape:White To Light YellowMolecular weight:240.21Rufinamide
CAS:<p>Applications Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. Neuroprotective & Neuroresearch Product.<br>References Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995), Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998), Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),<br></p>Formula:C10H8F2N4OColor and Shape:White To Off-WhiteMolecular weight:238.19Rufinamide
CAS:Controlled Product<p>Anti-convulsant possibly via volted-gated sodium channel modulation</p>Formula:C10H8F2N4OPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:238.19 g/mol
