CAS 106308-44-5: Rufinamide

Description: Rufinamide is an anticonvulsant medication primarily used in the treatment of Lennox-Gastaut syndrome, a severe form of epilepsy. It is characterized by its chemical formula, which includes a unique structure that allows it to modulate sodium channels, thereby stabilizing neuronal membranes and reducing seizure frequency. Rufinamide is typically administered orally and is known for its relatively favorable side effect profile compared to other antiepileptic drugs. The substance is soluble in organic solvents but has limited solubility in water, which can influence its bioavailability. Rufinamide's mechanism of action involves prolonging the inactivation of sodium channels, which helps to prevent the rapid firing of neurons associated with seizures. Additionally, it is metabolized in the liver, primarily through hydrolysis, and has a half-life that supports twice-daily dosing. Overall, Rufinamide represents an important therapeutic option for patients with refractory epilepsy, contributing to improved seizure control and quality of life.

Formula: C₁₀H₈F₂N₄O

InChI: InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)

InChI key: InChIKey=POGQSBRIGCQNEG-UHFFFAOYSA-N

SMILES: O=C(N)C=1N=NN(C1)CC=2C(F)=CC=CC2F

Synonyms:

• 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
• 1-[(2,6-Difiuorophenyl)methyl]-1H-1,2,3-triazole-4 carboxamide
• 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
• 1H-1,2,3-Triazole-4-Carboxamide, 1-[(2,6-Difluorophenyl)Methyl]-
• Banzel
• Cgp 33101
• E 2080
• Inovelon
• Ruf 331

Rufinamide

CAS: 106308-44-5

Anticonvulsants, hypnotics and sedatives

• Formula: C₁₀H₈F₂N₄O
• Color and Shape: White Crystalline Powder
• Molecular weight: 238.06662

Rufinamide

CAS: 106308-44-5

• Formula: C₁₀H₈F₂N₄O
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 238.1935

Rufinamide

CAS: 106308-44-5

• Formula: C₁₀H₈F₂N₄O
• Molecular weight: 238.19

Rufinamide

CAS: 106308-44-5

• Formula: C₁₀H₈F₂N₄O
• Color and Shape: White To Off-White Solid
• Molecular weight: 238.20

Rufinamide

CAS: 106308-44-5

• Formula: C₁₀H₈F₂N₄O
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 238.20

Rufinamide

CAS: 106308-44-5

• Formula: C₁₀H₈F₂N₄O
• Color and Shape: Neat
• Molecular weight: 238.19

Rufinamide

CAS: 106308-44-5

Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the …

• Formula: C₁₀H₈F₂N₄O
• Purity: 99.07% - 99.89%
• Color and Shape: White Powder
• Molecular weight: 238.19

Rufinamide

CAS: 106308-44-5

Applications Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant. Neuroprotective & …

• Formula: C₁₀H₈F₂N₄O
• Color and Shape: White To Off-White
• Molecular weight: 238.19

Rufinamide-d2

CAS: 106308-44-5

Applications Labelled Rufinamide (R701552). Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. …

• Formula: C₁₀H₆D₂F₂N₄O
• Color and Shape: White To Light Yellow
• Molecular weight: 240.21

Rufinamide

CAS: 106308-44-5

Anti-convulsant possibly via volted-gated sodium channel modulation

• Formula: C₁₀H₈F₂N₄O
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 238.19 g/mol

Rufinamide

CAS: 106308-44-5

• Formula: C₁₀H₈F₂N₄O
• Color and Shape: Neat
• Molecular weight: 238.19