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CAS 106375-28-4

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omega-conotoxin gvia

Description:
Omega-conotoxin GVIA is a peptide derived from the venom of the marine cone snail, Conus geographus. It is classified as a neurotoxin and primarily functions as a selective blocker of N-type voltage-gated calcium channels (VGCCs), which play a crucial role in neurotransmitter release and neuronal excitability. This compound is composed of a sequence of amino acids that form a characteristic three-dimensional structure, enabling it to bind specifically to the calcium channels. Omega-conotoxin GVIA has garnered interest in pharmacological research due to its potential applications in pain management and neurological disorders, as it can modulate synaptic transmission. Its specificity for N-type channels makes it a valuable tool for studying calcium signaling in neurons. Additionally, the compound's stability and potency contribute to its utility in both basic research and potential therapeutic contexts. As with many conotoxins, safety and dosage considerations are paramount due to its potent biological activity.
Formula:C120H182N38O43S6
Synonyms:
  • w-Conotoxin GVIA, Conus geographus
  • H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys19/ Cys15 and Cys26)
  • o-Conotoxin GVIA
  • CKS(Hyp)GSSCS(Hyp)TSYNCCRSCN(Hyp)YTKRCY-NH2
  • L-Tyrosinamide, L-cysteinyl-L-lysyl-L-seryl-(4R)-4-hydroxy-L-prolylglycyl-L-seryl-L-seryl-L-cysteinyl-L-seryl-(4R)-4-hydroxy-L-prolyl-L-threonyl-L-seryl-L-tyrosyl-L-asparaginyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-seryl-L-cysteinyl-L-asparaginyl-(4R)-4-hydroxy-L-prolyl-L-tyrosyl-L-threonyl-L-lysyl-L-...
  • OMEGA-CONOTOXIN GVIA ISOMER
  • ω-conotoxin gvia
  • CKS(HYP)GSSCS(HYP)TSYNCCRSCN(HYP)TKRCY-NH2
  • CYS-LYS-SER-HYP-GLY-SER-SER-CYS-SER-HYP-THR-SER-TYR-ASN-CYS-CYS-ARG-SER-CYS-ASN-HYP-TYR-THR-LYS-ARG-CYS-TYR-NH2
  • ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem
  • See more synonyms
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Found 5 products.
  • ω-Conotoxin GVIA
    Bachem
    + Info

    ω-Conotoxin GVIA

    CAS:
    ω-Conotoxin GVIA from the venom of the fish-hunting cone snail Conus geographus efficiently blocks neuronal calcium channels. This presynaptic inhibition of calcium influx prevents the voltage-activated release of acetylcholine.
    Formula:C120H182N38O43S6
    Purity:98.1%
    Color and Shape:White Lyophilisate
    Molecular weight:3037.39

    Ref: 01-4016306

    1mg
    679.00€
    0.5mg
    375.00€
  • ω-Conotoxin GVIA
    Targetmol
    + Info

    ω-Conotoxin GVIA

    CAS:
    <p>Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.</p>
    Formula:C120H182N38O43S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3037

    Ref: TM-TP2062

  • ω-Conotoxin GVIA
    Glentham
    + Info

    ω-Conotoxin GVIA

    CAS:
    Formula:C120H182N38O43S6
    Molecular weight:3037.35

    Ref: 7W-GK4252

    ne
    To inquire
  • ω-Conotoxin GVIA trifluoroacetate salt
    Biosynth
    + Info

    ω-Conotoxin GVIA trifluoroacetate salt

    Controlled Product
    CAS:
    <p>Omega-Conotoxin GVIA is a type of toxin from the venom of the marine snail Conus geographus. It binds to the kappa-opioid receptor, which is found on neurons in the central and peripheral nervous system. This binding inhibits voltage-dependent calcium channels and leads to neuronal death. Omega-Conotoxin GVIA has been shown to inhibit diastolic pressure in rats, as well as glomerular filtration rate (GFR) and kappa-opioid receptors in mice. The inhibition of GFR may be due to its effect on Ca2+ signaling, leading to decreased activity of the Na/K ATPase pump in proximal tubules.</p>
    Formula:C120H182N38O43S6
    Purity:Min. 95%
    Molecular weight:3,037.36 g/mol

    Ref: 3D-FC109903

    1mg
    1,428.00€
    250µg
    863.00€
    500µg
    1,037.00€
  • ω-Conotoxin GVIA
    Biosynth
    + Info

    ω-Conotoxin GVIA

    CAS:
    <p>Omega-Conotoxin GVIA is a peptide toxin that binds to the nicotinic acetylcholine receptor (nAChR) and blocks its function. It has been shown to be an inhibitor of voltage-gated potassium channels, which are responsible for regulating the electrical activity in cells. Omega-conotoxin GVIA is purified with a high degree of purity and has been shown to have no significant cross-reactivity with other nAChR subtypes. This toxin can be used as a research tool to study nAChR physiology or as an antibody to target this receptor in cell biology experiments.</p>
    Formula:C120H182N38O43S6
    Purity:Min. 95%
    Molecular weight:3,037.3 g/mol

    Ref: 3D-PCN-4161-V

    500µg
    1,344.00€