Peptide YY (PYY) is a 36-amino acid peptide hormone primarily secreted by the L cells in the gastrointestinal tract, particularly in response to food intake. It plays a crucial role in regulating appetite and energy balance by inhibiting gastric motility and promoting satiety. PYY is part of the neuropeptide Y (NPY) family and exists in several forms, with PYY3-36 being the most biologically active variant. The hormone functions by binding to specific receptors in the brain, particularly the Y2 receptor, which influences feeding behavior and energy expenditure. In addition to its appetite-regulating properties, PYY is involved in various physiological processes, including the modulation of insulin secretion and gastrointestinal motility. Its secretion is stimulated by the presence of nutrients in the gut, particularly fats and carbohydrates, making it an important factor in postprandial metabolism. Dysregulation of PYY levels has been associated with obesity and metabolic disorders, highlighting its potential as a therapeutic target for weight management and related conditions.

Peptide YY is released postprandially from intestinal
L cells as a satiety signal. In 1980, PYY was isolated and identified from the porcine intestine by means of a unique chemical assay identifying the C-terminal amide structure.

Peptide YY

106388-42-5: Peptide YY (PYY) is a 36-amino acid peptide hormone primarily secreted by the L cells in the gastrointestinal tract, particularly in response to food intake. It plays a crucial role in regulating appetite and energy balance by inhibiting gastric motility and promoting satiety. PYY is part of the neuropeptide Y (NPY) family and exists in several forms, with PYY3-36 being the most biologically active variant. The hormone functions by binding to specific receptors in the brain, particularly the Y2 receptor, which influences feeding behavior and energy expenditure. In addition to its appetite-regulating properties, PYY is involved in various physiological processes, including the modulation of insulin secretion and gastrointestinal motility. Its secretion is stimulated by the presence of nutrients in the gut, particularly fats and carbohydrates, making it an important factor in postprandial metabolism. Dysregulation of PYY levels has been associated with obesity and metabolic disorders, highlighting its potential as a therapeutic target for weight management and related conditions.

CAS 106388-42-5

Peptide YY