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CAS 106463-19-8

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(S)-Tamsulosin Hydrochloride

Description:
(S)-Tamsulosin Hydrochloride is a pharmaceutical compound primarily used in the treatment of benign prostatic hyperplasia (BPH), a condition characterized by an enlarged prostate. It is an alpha-1 adrenergic receptor antagonist, which works by selectively blocking alpha-1A receptors in the prostate and bladder neck, leading to relaxation of smooth muscle and improved urinary flow. The substance is a white to off-white crystalline powder, soluble in water and organic solvents like methanol and ethanol. Its molecular formula is C20H28N2O5S·HCl, and it has a chiral center, with the (S) configuration being the active form. The compound is typically administered orally, and its pharmacokinetics include a relatively short half-life, necessitating once-daily dosing. Side effects may include dizziness, headache, and orthostatic hypotension. As with any medication, it is essential to use (S)-Tamsulosin Hydrochloride under medical supervision to manage potential interactions and contraindications effectively.
Formula:C20H29ClN2O5S
InChI:InChI=1/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m0./s1
SMILES:CCOc1ccccc1OCCN[C@@H](C)Cc1ccc(c(c1)S(=O)(=O)N)OC.Cl
Synonyms:
  • 5-[(2S)-2-[[2-(-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride
  • S-(+)-Ym 12617
  • Ym 12617-2
  • Benzenesulfonamide, 5-[(2S)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride (9CI)
  • Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride, (S)-
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