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CAS 1064684-44-1

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Sofosbuvir

Description:
Sofosbuvir is an antiviral medication primarily used in the treatment of hepatitis C virus (HCV) infections. It is classified as a nucleotide analog polymerase inhibitor, specifically targeting the HCV NS5B polymerase, which is essential for viral replication. Sofosbuvir is characterized by its ability to inhibit the replication of the virus, thereby reducing the viral load in infected individuals. The chemical structure of Sofosbuvir includes a phosphoramidate prodrug that is converted into its active form within the body. It is typically administered orally and is often used in combination with other antiviral agents to enhance efficacy and reduce the risk of resistance. Sofosbuvir has a favorable pharmacokinetic profile, with a long half-life allowing for once-daily dosing. Common side effects may include fatigue, headache, and nausea, but it is generally well-tolerated. Its introduction has significantly improved treatment outcomes for patients with chronic hepatitis C, contributing to higher cure rates and better overall management of the disease.
Formula:C22H29FN3O9P
Synonyms:
  • Psi 7977
  • L-Alanine, N-[[p(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-p-phenyl-5'-uridylyl]-, 1-methylethyl ester
  • (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
  • Sofosvuvir Form6
  • sovaldi API
  • Sofosbuvir Form6
  • Gs-7977
  • Sopropyl-(2S)-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl]-4-fluoro-3-hydroxy-4-methy-ltetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate
  • Sofasbuvir
  • Sofosbuvir(cGMP)
  • (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4 dihydropryimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2yl) methoxy)(phenoxy)phosphoryl)amino) propanoate
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