The chemical substance known as "(5xi,13alpha,14beta,23R)-23-hydroxy-15,21-epoxylanosta-7,9(11),24-triene-3,21-dione," with the CAS number 106533-51-1, is a steroid derivative characterized by its complex molecular structure, which includes multiple functional groups such as hydroxyl and epoxide moieties. This compound features a lanostane backbone, a type of triterpenoid, which is significant in various biological activities. The presence of the hydroxyl group suggests potential for hydrogen bonding, influencing its solubility and reactivity. The epoxide group indicates a reactive site that can participate in further chemical transformations. This compound is of interest in pharmacological research due to its potential therapeutic properties, including anti-inflammatory and anticancer activities. Its stereochemistry, denoted by the specific alpha and beta configurations, plays a crucial role in determining its biological interactions and efficacy. Overall, this compound exemplifies the complexity and diversity of steroidal structures in organic chemistry and their relevance in medicinal applications.

Nimolinone is presented in EENL. Analysis of the compounds in the EENL by mass spectrometry suggests the presence of nimbolide, 2',3'-dehydrosalannol, 6-desacetyl nimbinene, and nimolinone. Antiproliferative activity of nimbolide and 2',3'-dehydrosalannol in HUVECs. EENL by regulating the genes involved in cellular development and cell death functions could control cell proliferation, attenuate the stimulatory effects of VEGF, and exert antiangiogenic effects. EENL treatment could have a potential therapeutic role during cancer progression.

(5xi,13alpha,14beta,23R)-23-hydroxy-15,21-epoxylanosta-7,9(11),24-triene-3,21-dione

106533-51-1: The chemical substance known as "(5xi,13alpha,14beta,23R)-23-hydroxy-15,21-epoxylanosta-7,9(11),24-triene-3,21-dione," with the CAS number 106533-51-1, is a steroid derivative characterized by its complex molecular structure, which includes multiple functional groups such as hydroxyl and epoxide moieties. This compound features a lanostane backbone, a type of triterpenoid, which is significant in various biological activities. The presence of the hydroxyl group suggests potential for hydrogen bonding, influencing its solubility and reactivity. The epoxide group indicates a reactive site that can participate in further chemical transformations. This compound is of interest in pharmacological research due to its potential therapeutic properties, including anti-inflammatory and anticancer activities. Its stereochemistry, denoted by the specific alpha and beta configurations, plays a crucial role in determining its biological interactions and efficacy. Overall, this compound exemplifies the complexity and diversity of steroidal structures in organic chemistry and their relevance in medicinal applications.

Nimolinone in EENL may regulate genes for cell growth/death, curb VEGF, and have antiangiogenic, anticancer potential.

CAS 106533-51-1

(5xi,13alpha,14beta,23R)-23-hydroxy-15,21-epoxylanosta-7,9(11),24-triene-3,21-dione

Nimolinone

Ref: TM-T24534