CAS 1066-17-7

colistin

Description:

Colistin, also known as polymyxin E, is a polypeptide antibiotic that is primarily used to treat infections caused by multidrug-resistant Gram-negative bacteria. It is derived from the bacterium Bacillus polymyxa and exhibits a unique mechanism of action by disrupting the bacterial cell membrane, leading to cell death. Colistin is particularly effective against pathogens such as Pseudomonas aeruginosa and Acinetobacter baumannii. Its structure consists of a cyclic peptide with a fatty acid tail, which enhances its ability to interact with lipid membranes. Colistin is administered either intravenously or via inhalation, as it is poorly absorbed from the gastrointestinal tract. While it is a valuable therapeutic option, its use has been limited due to potential nephrotoxicity and neurotoxicity. Additionally, the emergence of colistin-resistant strains poses a significant challenge in clinical settings. As a result, careful monitoring and stewardship are essential when using colistin in treatment regimens.

Formula: C₅₂H₉₈N₁₆O₁₃

InChI: InChI=1/C53H100N16O13/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+/m1/s1

Synonyms:

• Colimycin
• Colisticina
• Colistina
• Colistine
• Colivet
• Colomycin
• Coly-Mycin
• Colymysins
• Kangdisu
• Kolimitsin
• N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]amino}-3-hydroxy-1-oxobutan-2-yl]amino}-1-oxobutan-2-yl]-6-methyloctanamide
• Polymyxin E
• Totazina
• Colistin
• Aids033059
• [(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(1S,4S,7R,10S,13S,16S,19S)-4,13,16-tris(2-aminoethyl)-19-[(1R)-1-hydroxyethyl]-10-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-7-(phenylmethyl)-3,6
• Polymyxin E1 sulfate
• PolyMyxin E coMplex
• Aids-033059
• 1264-72-8 (Sulfate)
• Colistin, ColiMycin M, BelcoMycin, ColyMycin, Torazin

Colistin

CAS: 1066-17-7

Formula: C₁₀₅H₁₉₈N₃₂O₂₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 2324.8944

Ref: IN-DA01EH4E

Colistin

CAS: 1066-17-7

Colistin: polypeptide antibiotic for Gram-negative bacteria, including drug-resistant strains, but may cause nephrotoxicity.

Formula: C₅₃H₁₀₀N₁₆O₁₃(forE₁)

Color and Shape: Solid

Molecular weight: 1169.5

Ref: TM-T73798

Polymixin E complex

CAS: 1066-17-7

Molecular weight: 1169.5

Ref: 7W-GA1107

Colistin

CAS: 1066-17-7

Membrane-disrupting agent; cationic peptide

Formula: C₅₂H₉₈N₁₆O₁₃

Purity: Min. 95%

Molecular weight: 1,155.43 g/mol

Ref: 3D-FC153224

Colistin

CAS: 1066-17-7

Formula: C₅₂H₉₈N₁₆O₁₃

Molecular weight: 1155.5

Ref: ST-EA-CP-C116012