CAS 106610-60-0

3′-Hydroxy-4′-methoxydiclofenac

Description:

3′-Hydroxy-4′-methoxydiclofenac, with the CAS number 106610-60-0, is a derivative of diclofenac, a widely used non-steroidal anti-inflammatory drug (NSAID). This compound features a hydroxyl group at the 3′ position and a methoxy group at the 4′ position of the phenyl ring, which alters its pharmacological properties compared to its parent compound. It is characterized by its anti-inflammatory and analgesic activities, making it relevant in the treatment of pain and inflammatory conditions. The presence of the hydroxyl and methoxy groups can influence its solubility, stability, and bioavailability. Additionally, this compound may exhibit a different safety profile and efficacy compared to diclofenac, which is important for therapeutic applications. Its chemical structure allows for potential interactions with biological targets, particularly cyclooxygenase enzymes, which are involved in the inflammatory process. As with many pharmaceutical compounds, understanding its pharmacokinetics and pharmacodynamics is crucial for assessing its therapeutic potential and safety in clinical use.

Formula: C₁₅H₁₃Cl₂NO₄

InChI: InChI=1S/C15H13Cl2NO4/c1-22-11-7-9(16)14(13(17)15(11)21)18-10-5-3-2-4-8(10)6-12(19)20/h2-5,7,18,21H,6H2,1H3,(H,19,20)

InChI key: InChIKey=YALZBLAHGKGDMB-UHFFFAOYSA-N

SMILES: N(C1=C(Cl)C(O)=C(OC)C=C1Cl)C2=C(CC(O)=O)C=CC=C2

Synonyms:

• 2-[(2,6-Dichloro-3-hydroxy-4-methoxyphenyl)amino]benzeneacetic acid
• Benzeneacetic acid, 2-[(2,6-dichloro-3-hydroxy-4-methoxyphenyl)amino]-
• {2-[(2,6-Dichloro-3-Hydroxy-4-Methoxyphenyl)Amino]Phenyl}Acetic Acid
• 3'-Hydroxy-4'-methoxydiclofenac
• 3′-Hydroxy-4′-methoxydiclofenac

Diclofenac Impurity 8

CAS: 106610-60-0

Formula: C₁₅H₁₃Cl₂NO₄

Molecular weight: 342.17

Ref: 4Z-D-0646

3'-Hydroxy-4'-methoxydiclofenac

Controlled Product

CAS: 106610-60-0

Applications 3'-Hydroxy-4'-methoxydiclofenac is a derivative of Diclofenac (Sodium Salt: D436450). Diclofenac is the first non-steroidal anti-inflammatory drug (NSAID) that is derived from phenylacetic acid. Diclofenac, like other NSAIDs, primarily works by targeting the cyclo-oxygenase pathway in the arachidonic acid cascade, reducing the formation of inflammation mediators in the body.
References Ku, E., et al.: Am. J. Med., 80, 18 (1986); Simmons, D., et al.: Proc. Nat. Acad. Sci., 96, 3275 (1999); Small, R.: Clin. Pharm., 8, 545 (1989)

Formula: C₁₅H₁₃Cl₂NO₄

Color and Shape: Neat

Molecular weight: 342.17

Ref: TR-H946710

3'-Hydroxy-4'-methoxydiclofenac

CAS: 106610-60-0

3'-Hydroxy-4'-methoxydiclofenac is a potent anticancer agent that induces apoptosis in cancer cells. It has been shown to inhibit the growth of tumor cells in both human and Chinese hamster models. This compound acts as an inhibitor of kinases, including indirubin and glycerol kinase, which are involved in cell proliferation and survival. 3'-Hydroxy-4'-methoxydiclofenac is an analog of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief. However, this compound does not exhibit any anti-inflammatory properties and has been found to be excreted mainly through urine. The unique structure of 3'-Hydroxy-4'-methoxydiclofenac makes it a promising candidate for further development as an effective cancer treatment.

Formula: C₁₅H₁₃Cl₂NO₄

Purity: Min. 95%

Molecular weight: 342.2 g/mol

Ref: 3D-GEA61060

3\'-Hydroxy-4\'-methoxydiclofenac

CAS: 106610-60-0

Formula: C₁₅H₁₃Cl₂NO₄

Molecular weight: 342.17

Ref: ST-EA-CP-D20085