CAS 106635-80-7: Tafenoquine

Description: Tafenoquine is an antimalarial drug primarily used for the prevention and treatment of malaria, particularly in areas where Plasmodium vivax is prevalent. It is a synthetic 8-aminoquinoline compound that acts by targeting the liver stages of the malaria parasite, thereby preventing relapse of the disease. Tafenoquine is characterized by its long half-life, allowing for a single-dose regimen for prophylaxis, which enhances patient compliance compared to traditional treatments that require multiple doses. The compound exhibits a high affinity for the malaria parasite and is effective against both the blood and liver stages of the parasite's lifecycle. Tafenoquine is generally well-tolerated, but it may cause side effects such as gastrointestinal disturbances and, in rare cases, hemolytic anemia, particularly in individuals with glucose-6-phosphate dehydrogenase deficiency. Its development represents a significant advancement in malaria treatment strategies, particularly in the context of global health initiatives aimed at eradicating malaria.

Formula: C₂₄H₂₈F₃N₃O₃

InChI: InChI=1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3

InChI key: InChIKey=LBHLFPGPEGDCJG-UHFFFAOYSA-N

SMILES: FC(F)(F)C=1C=CC=C(OC2=C(OC)C=C(NC(C)CCCN)C3=NC(OC)=CC(=C32)C)C1

Synonyms:

• (R)-N3-(2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1,4-diamine
• (RS)-N(sup 3)-(2,6-Dimethoxy-4-methyl-5-(3-trifluoro-methylphenoxy)quinolin-8-yl)pentane-1,4-diamine
• 1,4-Pentanediamine, N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)-
• 1,4-Pentanediamine, N⁴-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-
• N(4)-(2,6-Dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine
• N⁴-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,4-pentanediamine
• N~4~-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine
• Sb 252263Aab
• Tafenoquine [INN:BAN]
• Unii-262P8Gs9L9
• Wr 238605

Tafenoquine

CAS: 106635-80-7

• Formula: C₂₄H₂₈F₃N₃O₃
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 463.4926

Tafenoquine

CAS: 106635-80-7

• Formula: C₂₄H₂₈F₃N₃O₃
• Molecular weight: 463.50

Tafenoquine

CAS: 106635-80-7

• Formula: C₂₄H₂₈F₃N₃O₃
• Color and Shape: Dark Orange
• Molecular weight: 463.49

Tafenoquine

CAS: 106635-80-7

Tafenoquine is an 8-aminoquinoline,and is an agent of anti-malarial prophylactic.

• Formula: C₂₄H₂₈F₃N₃O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 463.49

Tafenoquine

CAS: 106635-80-7

Tafenoquine is a drug that is used to treat malaria. It binds to the mitochondrial …

• Formula: C₂₄H₂₈F₃N₃O₃
• Purity: Min. 95%
• Molecular weight: 463.5 g/mol