CAS 106635-80-7

Tafenoquine

Description:

Tafenoquine is an antimalarial drug primarily used for the prevention and treatment of malaria, particularly in areas where Plasmodium vivax is prevalent. It is a synthetic 8-aminoquinoline compound that acts by targeting the liver stages of the malaria parasite, thereby preventing relapse of the disease. Tafenoquine is characterized by its long half-life, allowing for a single-dose regimen for prophylaxis, which enhances patient compliance compared to traditional treatments that require multiple doses. The compound exhibits a high affinity for the malaria parasite and is effective against both the blood and liver stages of the parasite's lifecycle. Tafenoquine is generally well-tolerated, but it may cause side effects such as gastrointestinal disturbances and, in rare cases, hemolytic anemia, particularly in individuals with glucose-6-phosphate dehydrogenase deficiency. Its development represents a significant advancement in malaria treatment strategies, particularly in the context of global health initiatives aimed at eradicating malaria.

Formula: C₂₄H₂₈F₃N₃O₃

InChI: InChI=1/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3

InChI key: InChIKey=LBHLFPGPEGDCJG-UHFFFAOYSA-N

SMILES: O(C=1C2=C(C(NC(CCCN)C)=CC1OC)N=C(OC)C=C2C)C3=CC(C(F)(F)F)=CC=C3

Synonyms:

• (R)-N3-(2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1,4-diamine
• (RS)-N(sup 3)-(2,6-Dimethoxy-4-methyl-5-(3-trifluoro-methylphenoxy)quinolin-8-yl)pentane-1,4-diamine
• 1,4-Pentanediamine, N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)-
• 1,4-Pentanediamine, N⁴-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-
• N(4)-(2,6-Dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine
• N⁴-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,4-pentanediamine
• N~4~-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine
• Sb 252263Aab
• Tafenoquine [INN:BAN]
• Unii-262P8Gs9L9
• Wr 238605
• Tafenoquine
• N4-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,4-pentanediamine
• N4-(2,6-diMethoxy-4-Methyl-5-(3-(trifluoroMethyl)phenoxy)quinolin-8-yl)pentane-1,4-diaMine
• SB 252263-AAB
• WR-238605, WR 238605, WR238605, SB-252263-AAB
• WR-238605, WR 238605, WR238605, SB-252263-AAB; SB252263-AAB; SB 252263-AAB; TAFENOQUINE; KRINTAFE
• WR 238605; WR238605; WR-238605; SB-252263; SB 252263; SB252263
• Krintafe
• SB252263-AAB
• tafenoquine,Etaquine,WR 238605,SB-252263
• 4-[5-[3-(Trifluoromethyl)phenoxy]-2,6-dimethoxy-4-methyl-8-quinolinylamino]-1-pentanamine

Tafenoquine

CAS: 106635-80-7

Formula: C₂₄H₂₈F₃N₃O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 463.4926

Ref: IN-DA008UZ3

Tafenoquine

CAS: 106635-80-7

Tafenoquine

Purity: ≥98%

Molecular weight: 463.49g/mol

Ref: 54-BUP21220

Tafenoquine

CAS: 106635-80-7

Formula: C₂₄H₂₈F₃N₃O₃

Molecular weight: 463.50

Ref: 4Z-T-426001

Tafenoquine

CAS: 106635-80-7

Tafenoquine (WR 238605) is an antimalarial prophylactic agent with schizonticidal activity, useful in hemolytic anemia research.

Formula: C₂₄H₂₈F₃N₃O₃

Purity: 99.56%

Color and Shape: Solid

Molecular weight: 463.49

Ref: TM-T13083

Tafenoquine

Controlled Product

CAS: 106635-80-7

Formula: C₂₄H₂₈F₃N₃O₃

Color and Shape: Dark Orange

Molecular weight: 463.49

Ref: TR-T004765