CAS 106635-81-8

(±)-8-(4-Amino-1-methylbutylamino)-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline succinate

Description:

The chemical substance known as (±)-8-(4-Amino-1-methylbutylamino)-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline succinate, with the CAS number 106635-81-8, is a synthetic compound that belongs to the class of quinoline derivatives. It features a complex molecular structure characterized by multiple functional groups, including amino, methoxy, and phenoxy moieties, which contribute to its biological activity. The presence of a trifluoromethyl group enhances its lipophilicity and may influence its pharmacokinetic properties. This compound is often studied for its potential therapeutic applications, particularly in the field of medicinal chemistry, where it may exhibit activity against certain diseases or conditions. Its succinate salt form suggests improved solubility and stability, which are critical for drug formulation. As with many synthetic compounds, understanding its mechanism of action, efficacy, and safety profile is essential for potential clinical applications. Further research is necessary to elucidate its full range of biological effects and therapeutic potential.

Formula: C₂₈H₃₂F₃N₃O₇

InChI: InChI=1/C24H28F3N3O3.C4H4O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES: Cc1cc(nc2c(cc(c(c12)Oc1cccc(c1)C(F)(F)F)OC)NC(C)CCCN)OC.C(=C\C(=O)O)\C(=O)O

Synonyms:

• Tafenoquine succinate
• Etaquine
• Sb-252263
• (±)-2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]primaquine succinate
• (±)-N4-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,4-pentanediamine butanedioate

Tafenoquine Succinate

CAS: 106635-81-8

Tafenoquine Succinate (WR 238605 (Succinate)) is an 8-aminoquinoline. and is an agent of anti-malarial prophylactic.

Formula: C₂₈H₃₄F₃N₃O₇

Purity: 99.77%

Color and Shape: Solid

Molecular weight: 581.58

Ref: TM-T13083L

WR-238605

CAS: 106635-81-8

Formula: C₂₈H₃₄F₃N₃O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 581.5807

Ref: IN-DA008WPX

N4-(2,6-Dimethoxy-4-Methyl-5-(3-(Trifluoromethyl)Phenoxy)Quinolin-8-Yl)Pentane-1,4-Diamine Succinate(1:1)

CAS: 106635-81-8

N4-(2,6-Dimethoxy-4-Methyl-5-(3-(Trifluoromethyl)Phenoxy)Quinolin-8-Yl)Pentane-1,4-Diamine Succinate(1:1)

Purity: 98%

Molecular weight: 581.58g/mol

Ref: 54-PC108464

Tafenoquine Succinate

CAS: 106635-81-8

Tafenoquine Succinate

Purity: ≥98%

Molecular weight: 581.58g/mol

Ref: 54-BUP04608

Tafenoquine Succinate

CAS: 106635-81-8

Formula: C₂₄H₂₈F₃N₃O₃·C₄H₆O₄

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 581.59

Ref: 3B-T4392

Tafenoquine Succinate

Controlled Product

CAS: 106635-81-8

Applications Tatenoquine is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
References McIntyre, J. A., et al.: Drugs. Future., 28, 859 (2003); LaMontagne, M.P., et al.: J. Medn. Chem., 32, 1728 (1989);

Formula: C₂₄H₂₈F₃N₃O₃·C₄H₆O₄

Color and Shape: Neat

Molecular weight: 581.58

Ref: TR-T004760